Calcitonin Gene Related Peptide (CGRP) II, rat TFA

Cat. No.: HY-P1913A Purity: 99.79%: FAQs
Data Sheet SDS COA Handling Instructions

Calcitonin Gene Related Peptide (CGRP) II, rat TFA, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II TFA can be used in the research of cardiovascular diseases.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Calcitonin Gene Related Peptide (CGRP) II, rat TFA Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Calcitonin Gene Related Peptide (CGRP) II, rat TFA:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Calcitonin Gene Related Peptide (CGRP) II, rat TFA induces vasodilator effects in small-diameter pig left anterior descending (LAD) coronary arteries with an EC₅₀ value of 0.56 nM^[1].
Calcitonin Gene Related Peptide (CGRP) II, rat TFA relaxes the spontaneous tone in isolated internal anal sphincter (IAS) strips, with an EC₅₀ value of 83 μM^[2].
Calcitonin Gene Related Peptide (CGRP) II, rat TFA (rβCGRP) inhibits [¹²⁵I]hαCGRP binding (IC₅₀: 7 nM), and stimulates cAMP accumulation (EC₅₀: 0.56 nM) in the cells co-expressing mRAMP1 (mouse receptor-activity-modifying-protein 1) and rCRLR (rat calcitonin receptor-like receptor)^[3].
Calcitonin Gene Related Peptide (CGRP) II, rat TFA (rat-βCGRP, 0.01-100 nM) induces endothelium-independent relaxations in the coronary arteries from male and female Sprague-Dawley rats, with an IC₅₀ value of 2.8 nM approximately^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Calcitonin Gene Related Peptide (CGRP) II, rat TFA (rat-βCGRP, bolus injection, 0.3 μg/kg, at 10 min intervals) induces hypotension and vasodilatation in Male Sprague-Dawley rats^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats^[5]
Dosage:	0.01 ng/kg-3 μg/kg (100 μL), succeeded by a 150 μL isotonic saline flush, at 10 min intervals.
Administration:	A bolus injection
Result:	Induced PA (pial artery) dilatation and increased in LCBF_Flux (local cortical cerebral blood flow).

Molecular Weight

3919.33

Appearance

Solid

Formula

C₁₆₅H₂₆₈F₃N₅₁O₅₂S₂

Sequence

Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSKAF-NH2 (Disulfide bridge: Cys2-Cys7)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (6.38 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.2551 mL	1.2757 mL	2.5515 mL
5 mM	0.0510 mL	0.2551 mL	0.5103 mL
10 mM	---	---	---

*Please refer to the solubility information to select the appropriate solvent.

Purity & Documentation

Purity: 99.79%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (239 KB) LCMS (240 KB)

Handling Instructions (2659 KB)

References

[1]. D Wu, et al. Development and potential of non-peptide antagonists for calcitonin-gene-related peptide (CGRP) receptors: evidence for CGRP receptor heterogeneity. Biochem Soc Trans. 2002 Aug;30(4):468-73. [Content Brief]

[2]. F M Wisskirchen, et al. CGRP(2) receptor in the internal anal sphincter of the rat: implications for CGRP receptor classification. Br J Pharmacol. 2000 May;130(2):464-70. [Content Brief]

[3]. K Husmann, et al. Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol Cell Endocrinol. 2000 Apr 25;162(1-2):35-43. [Content Brief]

[4]. M Sheykhzade, et al. Characterization of calcitonin gene-related peptide (CGRP) receptors in intramural coronary arteries from male and female Sprague Dawley rats. Br J Pharmacol. 1998 Apr;123(7):1464-70. [Content Brief]

[5]. Kenneth A Petersen, et al. Inhibitory effect of BIBN4096BS on cephalic vasodilatation induced by CGRP or transcranial electrical stimulation in the rat. Br J Pharmacol. 2004 Nov;143(6):697-704. [Content Brief]