1582205-90-0
1582205-90-0
Chemical Structure
Erenumab
Synonym(s): AMG-334
- CAS No.: 1582205-90-0
- Formula:N/A
- Molecular Weight:(145.5 kDa)
SMILES: [Erenumab]
Biological Activity: Erenumab (AMG-334) is a fully human monoclonal antibody. Erenumab inhibits the calcitonin gene-related peptide (CGRP) receptor. Erenumab prevents the increase in dermal blood flow in cynomolgus monkeys. Erenumab can be used in the research of episodic migraine[1][2][3].
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Erenumab | 98.88% | Erenumab (AMG-334) is a fully human monoclonal antibody. Erenumab inhibits the calcitonin gene-related peptide (CGRP) receptor. Erenumab prevents the increase in dermal blood flow in cynomolgus monkeys. Erenumab can be used in the research of episodic migraine. | ||||||||||||||||||||
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References
- [1]. Shi L, et al. Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide Receptor. J Pharmacol Exp Ther. 2016 Jan;356(1):223-31. [Content Brief]
- [2]. Reuter U, et al. Erenumab versus topiramate for the prevention of migraine - a randomised, double-blind, active-controlled phase 4 trial. Cephalalgia. 2022;42(2):108-118. [Content Brief]
- [3]. Ohlsson L, et al. Erenumab (AMG 334), a monoclonal antagonist antibody against the canonical CGRP receptor, does not impair vasodilatory or contractile responses to other vasoactive agents in human isolated cranial arteries. Cephalalgia. 2019;39(14):1745-1752. [Content Brief]
Keywords
