Catechol O-methyltransferase, porcine liver
Based on 1 Customer Validation
Catechol O-methyltransferase, porcine liver (COMT), the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain.
For research use only. We do not sell to patients.
- CAS No.: 9012-25-3
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Instructions
Water-soluble enzymes can be used and 1% BSA can be added when dissolving. The solution should be freshly prepared.
Or dissolve according to the specific experimental reference.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
2.1.1.6
>2000 U/mg soild
One unit is defined as the amount of enzyme that will catalyze the methylation of 1nmol of dihydroxybenzoic acid per hour at 37°C, pH 8.0, using S-adenosyl-L- (methyl14C) -methionine as the methyl donor.
Chemical Information
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CAS No. 9012-25-3
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Appearance Solid
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Color White to off-white
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SMILES
[Catechol O-methyltransferase]
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Synonyms
COMT
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Catechol O-methyltransferase, porcine liver Related Classifications
HY-E70007 Related Classifications
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