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Art. -Nr.: HY-N0992

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1,6,7-Trihydroxyxanthone

1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16.

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CAS. Nr.: 25577-04-2
Formel: C₁₃H₈O₅
Molecular Weight:244.20

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

1,6,7-Trihydroxyxanthone Chemical Structure

CAS. Nr.: 25577-04-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
COLO 320	IC₅₀	85.1 μM Compound: 45375	Antiproliferative activity against human COLO320 cells after 48 hrs by CCK8 assay Antiproliferative activity against human COLO320 cells after 48 hrs by CCK8 assay	[PMID: 28376372]
HepG2	IC₅₀	83.8 μM Compound: 45375	Antiproliferative activity against human HepG2 cells after 48 hrs by CCK8 assay Antiproliferative activity against human HepG2 cells after 48 hrs by CCK8 assay	[PMID: 28376372]
K562	IC₅₀	155.7 μM Compound: 45375	Antiproliferative activity against human K562 cells after 48 hrs by CCK8 assay Antiproliferative activity against human K562 cells after 48 hrs by CCK8 assay	[PMID: 28376372]
MCF7	IC₅₀	101 μM Compound: 45375	Antiproliferative activity against human MCF7 cells after 48 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells after 48 hrs by CCK8 assay	[PMID: 28376372]
MDA-MB-231	IC₅₀	65.9 μM Compound: 45375	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by CCK8 assay	[PMID: 28376372]

In Vitro

1,6,7-Trihydroxyxanthone (0-10 µg/mL; 0-72 h) inhibits cell proliferation in HepG2, Bel7404 cells^[1].
1,6,7-Trihydroxyxanthone (5 µg/mL; 72 h) induces cell apoptosis in HepG2 cells^[1].
1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16^[1].
1,6,7-Trihydroxyxanthone induces MiR-218 up-regulation in HepG2, Bel7404 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HepG2, Bel7404 cells
Concentration:

0, 1.25, 2.5, 5, 10 µg/mL
Incubation Time:

0, 24, 48, 72 h
Result:

Inhibited cell proliferation of HepG2 and Bel7404 in a time- and dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

5 μg/ml
Incubation Time:

72 h
Result:

Induced cell apoptosis.

Western Blot Analysis^[1]

Cell Line:

HepG2, Bel7404 cells
Concentration:
Incubation Time:
Result:

Suppressed Bmi-1 expressio and increased the expression of P14, P16 protein levels.

Chemical Information

CAS. Nr. 25577-04-2
Molecular Weight 244.20
Formel C₁₃H₈O₅
SMILES

O=C1C2=C(OC3=C1C=C(O)C(O)=C3)C=CC=C2O
Structure Classification
- Others
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fu WM, et al. MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells. Apoptosis. 2015 Jan;20(1):75-82. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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