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Art. -Nr.: HY-N17999

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10-Hydroxypheophorbide A

10-Hydroxypheophorbide A is a chlorophyll-related compound found in the leaves of
Neptunia oieracea. 10-Hydroxypheophorbide A inhibits the activation of tumor promoter-induced Epstein-Barr virus (EBV) activation. 10-Hydroxypheophorbide A exhibits photo-induced cytotoxicity in cancer cells.

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CAS. Nr.: 83688-53-3
Formel: C₃₅H₃₆N₄O₆
Molecular Weight:608.68

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

10-Hydroxypheophorbide A Chemical Structure

CAS. Nr.: 83688-53-3

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Biologische Aktivität
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- Cellular Effect
- In Vitro
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Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
1A9	ED₅₀	1.2 μg/mL Compound: 3	Cytotoxicity against human 1A9 cells after 72 hrs by SRB assay Cytotoxicity against human 1A9 cells after 72 hrs by SRB assay	[PMID: 11473423]

In Vitro

10-Hydroxypheophorbide A (Compound 6) (0.05-50 μM) inhibits teleocidin B-4-induced EBV activation in Raji cells with an IC₅₀ of 18 μM, with increasing inhibitory activity observed at concentrations from 0.05 μM to 50 μM^[1].
10-Hydroxypheophorbide A exhibits photocytotoxicity in Raji cells, with a pLC₅₀ of 4.92 without irradiation and a pLC₅₀ of 7.06 with irradiation, indicating increased cytotoxicity with photo-exposure^[1].
10-Hydroxypheophorbide A (50 μM; 30 h) accelerates photo-induced ethyl linoleate peroxidation in a cell-free system, resulting in an OD₅₃₂ value of 0.426 at 50 μM after 30 h of irradiation^[1].
10-Hydroxypheophorbide A (0.5 μM) does not have its inhibitory activity against EBV activation in Raji cells significantly enhanced by photo-irradiation, with 0 ± 3% inhibition without irradiation and 2 ± 8% inhibition with irradiation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 83688-53-3
Molecular Weight 608.68
Formel C₃₅H₃₆N₄O₆
SMILES

COC([C@@]1(/C2=C([C@H]([C@@H]3C)CCC(O)=O)/N=C3/C=C(C(C)=C/4C=C)\NC4=C/C5=N/C(C(CC)=C5C)=C\C6=C(C)C(C1=O)=C2N6)O)=O
Structure Classification
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Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nakamura Y, et al. Identification of pheophorbide a and its related compounds as possible anti-tumor promoters in the leaves of Neptunia oleracea. Biosci Biotechnol Biochem. 1996;60(6):1028-1030. [Content Brief]

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Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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