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Art. -Nr.: HY-W012670

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2-Deoxy-L-ribose

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2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase.

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CAS. Nr.: 18546-37-7
Formel: C₅H₁₀O₄
Molecular Weight:134.13

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (270 KB)

2-Deoxy-L-ribose Chemical Structure

CAS. Nr.: 18546-37-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

2-Deoxy-L-ribose (10-100 μM; 24 h) significantly reduces the number of invading KB/TP cells under hypoxia^[1].
2-Deoxy-L-ribose (10-100 μM; 48 h) decreases VEGF and IL-8 mRNA levels in KB/TP cells under hypoxia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Invasion Assay^[1]

Cell Line:

KB/TP cells (thymidine phosphorylase (TP)-overexpressing human epidermoid carcinoma)
Concentration:

10 μM or 100 μM
Incubation Time:

24 hours
Result:

Inhibited TP-overexpressing tumor cell invasion in vitro.

RT-PCR^[1]

Cell Line:

KB/TP cells (thymidine phosphorylase (TP)-overexpressing human epidermoid carcinoma)
Concentration:

10 μM or 100 μM
Incubation Time:

48 hours
Result:

In Vivo

2-Deoxy-L-ribose (20-100 mg/kg; p.o.; daily; 28 days) reduces liver metastatic nodules and metastatic area, suppresses angiogenesis, and enhances apoptosis^[1].
2-Deoxy-L-ribose (20 mg/kg; p.o.; daily; 52 days) showes superior efficacy to Tegafur (HY-17400) (100 mg/kg) in reducing abdominal metastatic nodules^[1].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude mice intrasplenically injected with KB/TP cells^[1]
Dosage:

20 mg/kg/day or 100 mg/kg/day
Administration:

Oral (p.o.), daily for 28 days
Result:

Effectively inhibited TP-mediated liver metastasis and angiogenesis.

Animal Model:

BALB/c nude mice with subcutaneous KB/TP cell injection^[1]
Dosage:

20 mg/kg/day
Administration:

Oral (p.o.), daily until day 52
Result:

Decreased the number of metastatic nodules in organs.

Chemical Information

CAS. Nr. 18546-37-7
Appearance Solid
Molecular Weight 134.13
Formel C₅H₁₀O₄
Color White to light yellow
SMILES

O=CC[C@H]([C@H](CO)O)O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nakajima Y, et al. Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose. Cancer Res. 2004 Mar 1;64(5):1794-801. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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2-Deoxy-L-ribose

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2-Deoxy-L-ribose Related Classifications

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