7-Hydroxycoumarin glucuronide
Based on 1 Customer Validation
7-Hydroxycoumarin glucuronide is a transport substrate and main human coumarin metabolite.7-Hydroxycoumarin glucuronide undergoes ATP-dependent efflux transport via MRP3 and MRP4.7-Hydroxycoumarin glucuronide undergoes active transport processes for urinary excretion and is primarily excreted into urine in humans.
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- CAS. Nr.: 66695-14-5
- Formel: C15H14O9
- Molecular Weight:338.27
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
7-Hydroxycoumarin glucuronide (400 μM; 10-20 min) is a substrate of MRP3 (Km = 187 μM) and MRP4 (Km = 63 μM) efflux transporters, but not of MRP1, MRP2, BCRP, or P-gp, as demonstrated by ATP-dependent uptake in MRP3- and MRP4-overexpressing membrane vesicles[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 66695-14-5
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Appearance Solid
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Molecular Weight 338.27
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Formel C15H14O9
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SMILES
O=C1C=CC2=CC=C(C=C2O1)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (147.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9562 mL | 14.7811 mL | 29.5622 mL | 73.9055 mL |
| 5 mM | 0.5912 mL | 2.9562 mL | 5.9124 mL | 14.7811 mL | |
| 10 mM | 0.2956 mL | 1.4781 mL | 2.9562 mL | 7.3905 mL | |
| 15 mM | 0.1971 mL | 0.9854 mL | 1.9708 mL | 4.9270 mL | |
| 20 mM | 0.1478 mL | 0.7391 mL | 1.4781 mL | 3.6953 mL | |
| 25 mM | 0.1182 mL | 0.5912 mL | 1.1825 mL | 2.9562 mL | |
| 30 mM | 0.0985 mL | 0.4927 mL | 0.9854 mL | 2.4635 mL | |
| 40 mM | 0.0739 mL | 0.3695 mL | 0.7391 mL | 1.8476 mL | |
| 50 mM | 0.0591 mL | 0.2956 mL | 0.5912 mL | 1.4781 mL | |
| 60 mM | 0.0493 mL | 0.2464 mL | 0.4927 mL | 1.2318 mL | |
| 80 mM | 0.0370 mL | 0.1848 mL | 0.3695 mL | 0.9238 mL | |
| 100 mM | 0.0296 mL | 0.1478 mL | 0.2956 mL | 0.7391 mL |
7-Hydroxycoumarin glucuronide Related Classifications
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