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Art. -Nr.: HY-184791

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AChE-IN-120

AChE-IN-120 is a blood-brain barrier-permeable AChE inhibitor, with an IC₅₀ of 0.91 μM and a K_i of 1.027 μM against human AChE. AChE-IN-120 exerts neuroprotective effects against oxidative damage. AChE-IN-120 can be used for the research of Alzheimer's disease.

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Formel: C₂₃H₂₆FN₅OS
Molecular Weight:439.55

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AChE-IN-120 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

hAChE

0.91 μM (IC₅₀)

hAChE

1.027 μM (Ki)

BuChE

30.97 μM (IC₅₀)

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

In Vitro

AChE-IN-120 (Compound 11e) (0-8 μM) potently and selectively inhibits human acetylcholinesterase (AChE) via a mixed-type inhibition mechanism, with an IC₅₀ of 0.91 μM, while it only exhibits weak inhibitory activity against butyrylcholinesterase (BuChE) (IC₅₀ = 30.97 μM)^[1].
AChE-IN-120 (0.1-10 μM) exhibits low cytotoxicity against SH-SY5Y cells, and its viability inhibitory effect gradually weakens as the concentration decreases from 10 μM to 0.1 μM^[1].
AChE-IN-120 (0.1-10 μM) exerts significant neuroprotective effects against H₂O₂-induced damage in SH-SY5Y cells at the concentration of 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 439.55
Formel C₂₃H₂₆FN₅OS
SMILES

O=C1N(CC)C2=CC(F)=CC=C2/C1=N/NC(NC3CCN(CC3)CC4=CC=CC=C4)=S
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Sevinçli ZŞ, et al. Novel 2-indolinone benzylpiperidine- thiosemicarbazone hybrids as cholinesterase inhibitors: Design, synthesis and biological evaluation. Bioorganic chemistry. 2026 Jun 24;180:110150. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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AChE-IN-120

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

AChE-IN-120 Related Classifications

HY-184791 Related Classifications