AGN-190121
AGN-190121 is a selective RARβ/γ retinoid agonist that inhibits IL-6 expression and cell proliferation in cancer cells by antagonizing NF-IL6. AGN-190121 can be used for the research of Kaposi's sarcoma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 132032-67-8
- Formel: C20H22O2
- Molecular Weight:294.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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IL-6 |
AGN-190121 (0-1 μM; 5 days) inhibits the proliferation of KS-29 cells in vitro with an IC50 of 50 nM; it also inhibits the proliferation of KS-59 cells with an IC50 of 100 nM[1].
AGN-190121 (1 μM; 36 h) inhibits NF-IL6-dependent gene expression via RARα and RARβ in transfected HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KS-29, KS-59
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Concentration:0.1, 1, 10, 100, 1000 nM
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Incubation Time:treated on days 1 and 3, counted on day 5
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Result:Inhibited the growth of KS-29 and KS-59 cells in a dose-dependent manner.
Exhibited an IC50 of 50 nM for KS-29 cells.
Exhibited an IC50 of 100 nM for KS-59 cells.
Chemical Information
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CAS. Nr. 132032-67-8
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Molecular Weight 294.39
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Formel C20H22O2
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SMILES
C(=C/C#CC1=CC=C(C(O)=O)C=C1)\C=2C(C)(C)CCCC2C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AGN-190121 Related Classifications
HY-165521 Related Classifications
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