Antibacterial agent 326

Antibacterial agent 326 (Compound 12) at concentrations of 1.56-3.12 μg/mL inhibits the growth of S. aureus, E. faecalis, L. species, B. subtilis, S. marcescens, E. coli, S. enterica, and A. calcoaceticu, with MIC values of 1.56, 1.56, 3.12, 1.56, 3.23, 1.56, 3.12, and 1.56 μg/mL, respectively^[1].
Antibacterial agent 326 produces an inhibition zone of 22.7 mm against Escherichia coli in the agar disk diffusion assay, exhibiting strong antibacterial activity^[1].
Antibacterial agent 326 (0-12.5 μg/mL; up to 660 min) exhibits rapid, concentration-dependent bactericidal activity against E. coli, inhibits E. coli biofilm formation, increases the inner membrane permeability of E. coli, disrupts the membrane integrity of E. coli, and depolarizes the cell membrane of E. coli^[1].
Antibacterial agent 326 (1.56-12.5 μg/mL) induces concentration-dependent metabolic dysfunction in E. coli, triggers intracellular oxidative stress, elevates ROS levels, impairs the cellular antioxidant defense system, and reduces GSH activity^[1].
Antibacterial agent 326 (12.5 μg/mL) induces lipid peroxidation and increases MDA production in Escherichia coli^[1].
Antibacterial agent 326 disrupts the cellular morphology of E. coli, causing wrinkles, shrinkage, collapse, and fragmentation on its surface^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.