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Art. -Nr.: HY-187351

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BMX-IN-4

BMX-IN-4 is a covalent BMX kinase inhibitor with an IC₅₀ of 1.78 nM and a K_i of 0.158 μM. BMX-IN-4 forms a covalent bond with BMX kinase. BMX-IN-4 is applicable to the research of hepatocellular carcinoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3132799-96-0
Formel: C₂₁H₁₅ClN₄O₂S
Molecular Weight:422.89

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMX-IN-4 Chemical Structure

CAS. Nr.: 3132799-96-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

BMX-IN-4 (Compound 11i) potently inhibits recombinant BMX with an IC₅₀ of 1.78 nM; it exhibits 2.3-fold selectivity over recombinant BTK, and its activity is dependent on a covalent warhead^[1].
BMX-IN-4 achieves selective cellular target binding to BMX but not BTK in HEK293T cells, with an EC₅₀ of 0.098 μM against BMX and a selectivity window of 20.6-fold^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3132799-96-0
Molecular Weight 422.89
Formel C₂₁H₁₅ClN₄O₂S
SMILES

O=C(NC1=CN=C(C2=C1)NC=C2C3=CC=CC(NC(C=C)=O)=C3)C4=CC=C(S4)Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Liang XJ, et al. Riding toward Selectivity: Optimization of Covalent 7-Azaindole-Based BMX Kinase Inhibitors. Journal of medicinal chemistry. 2026 Jul 23;69(14):17416-17447. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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