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Art. -Nr.: HY-136406

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Bongkrekic acid

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Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport.

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Reinheit: 99.92%
CAS. Nr.: 11076-19-0
Formel: C₂₈H₃₈O₇
Molecular Weight:486.60

Speicherung:

Solution, -20°C, 2 years

Bongkrekic acid Chemical Structure

CAS. Nr.: 11076-19-0

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Beschreibung

Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans^[1]. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport^[2].

In Vitro

Bongkrekic acid (0-50 μM; 48 hours) stimulated formazan formation in MDA-MB-231, MCF-7 and LTED cells with EC₅₀ of 34.14 μM, >50 μM and 2.58 μM, respectively.
Bongkrekic acid (0.1-25 μM; 48 hours) decreases the living cell numbers in LTED cells and parent MCF-7 cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 11076-19-0
Appearance Liquid
Molecular Weight 486.60
Formel C₂₈H₃₈O₇
Color Colorless to light yellow
SMILES

OC(CC(/C=C/[C@@H](C)C/C=C/CC/C=C/C=C\C[C@@H](OC)/C(C)=C\C=C(C)\C(O)=O)=C/C(O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Solution, -20°C, 2 years

Publications (1)

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Cancer Commun (Lond)

2025 Dec 15.

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Reinheit: 99.98%

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ee.: 99.98%

Data Sheet (264 KB)
SDS (393 KB)
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COA (2659 KB)
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OR (2659 KB)
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Handling Instructions (2659 KB)

Verweise

[1]. Mehruba Anwar, et al. Bongkrekic Acid-a Review of a Lesser-Known Mitochondrial Toxin. J Med Toxicol. 2017 Jun;13(2):173-179. [Content Brief]

[2]. C Dahout-Gonzalez, et al. Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier. Physiology (Bethesda) [Content Brief]

[3]. Shuso Takeda, et al. Bongkrekic Acid as a Warburg Effect Modulator in Long-term Estradiol-deprived MCF-7 Breast Cancer Cells. Anticancer Res [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Bongkrekic acid

1 Cited Publications

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Bongkrekic acid

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