Captopril hydrochloride
Based on 23 publication(s) in Google Scholar
Captopril (SQ 14225) hydrochloride, antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril hydrochloride is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM.
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- CAS. Nr.: 198342-23-3
- Formel: C9H16ClNO3S
- Molecular Weight:253.75
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Captopril hydrochloride
More- Nat Commun. 2023 May 2;14(1):2523. [Abstract]
- Allergy. 2025 Nov 14. [Abstract]
- Phytomedicine. 2025 Sep 15:148:157263. [Abstract]
- Phytomedicine. 2024 May:127:155467. [Abstract]
- Phytomedicine. 2023 Dec:121:155118. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Apoptosis. 2024 Oct;29(9-10):1499-1514. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Eur J Med Chem. 2022 Mar 5:231:114121. [Abstract]
- Cell Rep Methods. 2023 Oct 23;3(10):100599. [Abstract]
- Eur J Pharmacol. 2025 Oct 15:1005:178045. [Abstract]
- Mar Drugs. 2023 Sep 29;21(10):522. [Abstract]
- Eur J Pharmacol. 2022 May 15;923:174892. [Abstract]
- Eur J Pharmacol. 2022 Apr 15:921:174871. [Abstract]
- Sci Rep. 2021 Mar 4;11(1):5241. [Abstract]
- J Cell Mol Med. 2022 Aug;26(16):4548-4555. [Abstract]
- Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H580-H592. [Abstract]
- J Orthop Surg Res. 2024 Feb 19;19(1):147. [Abstract]
- Front Oncol. 2021 Jun 16;11:663671. [Abstract]
- Arch Physiol Biochem. 2025 Apr;131(2):285-292. [Abstract]
- Medicine. 2023 Dec 15;102(50):e36177. [Abstract]
- bioRxiv. 2026 Jun 19.
- Biomed Pharmacother. 2024 Aug:177:117012. [Abstract]
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Biologische Aktivität
ACE[1]
Captopril (SQ 14225) hydrochloride has been shown to have similar morbidity and mortality benefits to those of diuretics and beta-blockers in hypertensive patients. Captopril hydrochloride has been shown to delay the progression of diabetic nephropathy, and enalapril and lisinopril prevent the development of nephropathy in normoalbuminuric patients with diabetes[4].
An equimolar ratio of the cis and trans states of Captopril hydrochloride exists in solution and that the enzyme selects only the trans state of the inhibitor that presents architectural and stereoelectronic complementarity with its substrate binding groove[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 198342-23-3
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Molecular Weight 253.75
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Formel C9H16ClNO3S
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SMILES
O=C(O)[C@H]1N(C([C@H](C)CS)=O)CCC1.Cl
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Synonyms
SQ 14225 hydrochloride
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (23)
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Journal Impact Factor
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Most Recent
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Nat Commun
Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. [Abstract]2023 May 2;14(1):2523. PMID: 37130842
Captopril hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 2;14(1):2523. [Abstract]
Serum BK levels from sWAT from WT male mice treated with 40 mg/kg/day Captopril or 70 mg/kg/day Enalapril by gavage once a day for 21 days. The results showed that Captopril significantly increased serum BK levels.
Captopril hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 2;14(1):2523. [Abstract]
Representative immunohistochemistry (IHC) staining of UCP1 and H&E staining of sWAT. Captopril (40 mg/kg; once daily; 21 days; 25°C) induced sWAT brownin.
Captopril hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 2;14(1):2523. [Abstract]
Captopril (40 mg/kg; once daily; 21 days; 25°C) decreased the weight of sWAT in WT male mice.
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Allergy
Long-Term Attenuation of Vascular Hyperpermeability in a Hereditary Angioedema Mouse Model by Adenine Base Editing. [Abstract]2025 Nov 14. PMID: 41236489
Captopril hydrochloride purchased from MedChemExpress. Usage Cited in: Allergy. 2025 Nov 14. [Abstract]
Representative images of feet collected 30 min post-Evans Blue (EB) injection. Mice were assigned to five groups: WT control, Serping1+/− control, WT + Captopril (2.5 mg/kg; i.v.), Serping1+/− + Captopril + PBS, and Serping1+/− + Captopril + AAV-NG-ABE8e. Captopril elicited significant Evans blue leakage.
Captopril hydrochloride purchased from MedChemExpress. Usage Cited in: Allergy. 2025 Nov 14. [Abstract]
Representative intravital confocal images showing real-time FITC-dextran extravasation from intestinal microvasculature. Mice were assigned to: WT control, Serping1+/− control, WT + Captopril (2.5 mg/kg; i.v.), Serping1+/− + Captopril + PBS, and Serping1+/− + Captopril + AAV-NG-ABE8e. By 30 min, Captopril-treated mice demonstrated pronounced FITC-dextran extravasation—both in area and fluorescence intensity—relative to WT and Serping1+/− controls.
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Phytomedicine
Shexiang baoxin pill ameliorates cardiac fibrosis by inhibiting fibroblast to myofibroblast transition through STAT3 phosphorylation suppression. [Abstract]2025 Sep 15:148:157263. PMID: 40975042 -
Phytomedicine
Quercitrin improves cardiac remodeling following myocardial infarction by regulating macrophage polarization and metabolic reprogramming. [Abstract]2024 May:127:155467. PMID: 38447360 -
Phytomedicine
Ethyl ferulate suppresses post-myocardial infarction myocardial fibrosis by inhibiting transforming growth factor receptor 1. [Abstract]2023 Dec:121:155118. PMID: 37801895 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Apoptosis
Targeting PAX8 sensitizes ovarian cancer cells to ferroptosis by inhibiting glutathione synthesis. [Abstract]2024 Oct;29(9-10):1499-1514. PMID: 38853202 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Eur J Med Chem
Development of targeted nanoparticles loaded with antiviral drugs for SARS-CoV-2 inhibition. [Abstract]2022 Mar 5:231:114121. PMID: 35114539 -
Cell Rep Methods
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]2023 Oct 23;3(10):100599. PMID: 37797618 -
Eur J Pharmacol
Captopril alleviates radiation-induced pulmonary fibrosis by suppressing PAI-1 expression and cytoskeleton-dependent epithelial-to-mesenchymal transition. [Abstract]2025 Oct 15:1005:178045. PMID: 40780595 -
Mar Drugs
Affinity Purification and Molecular Characterization of Angiotensin-Converting Enzyme (ACE)-Inhibitory Peptides from Takifugu flavidus. [Abstract]2023 Sep 29;21(10):522. PMID: 37888457 -
Eur J Pharmacol
Montelukast, cysteinyl leukotriene receptor 1 antagonist, inhibits cardiac fibrosis by activating APJ. [Abstract]2022 May 15;923:174892. PMID: 35358494 -
Eur J Pharmacol
Captopril alleviates glucocorticoid-induced osteonecrosis of the femoral head by mediating the ACE2/ Ang-(1-7)/Mas receptor cascade. [Abstract]2022 Apr 15:921:174871. PMID: 35283112 -
Sci Rep
Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography. [Abstract]2021 Mar 4;11(1):5241. PMID: 33664407 -
J Cell Mol Med
Pirfenidone alleviates cardiac fibrosis induced by pressure overload via inhibiting TGF-β1/Smad3 signalling pathway. [Abstract]2022 Aug;26(16):4548-4555. PMID: 35861038 -
Am J Physiol Heart Circ Physiol
Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system. [Abstract]2018 Mar 1;314(3):H580-H592. PMID: 29350998 -
J Orthop Surg Res
Several first-line anti-hypertensives act on fibrosarcoma progression and PD1ab blockade therapy. [Abstract]2024 Feb 19;19(1):147. PMID: 38373964 -
Front Oncol
The Angiotensin-Converting Enzyme Inhibitory State Promotes the Transformation of Non-Small Cell Lung Cancer Blood Supply Pattern Toward Vasculogenic Mimicry Formation. [Abstract]2021 Jun 16;11:663671. PMID: 34221978 -
Arch Physiol Biochem
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway. [Abstract]2025 Apr;131(2):285-292. PMID: 39329410 -
Medicine
Mechanism of Huaiqihuang in treatment of diabetic kidney disease based on network pharmacology, molecular docking and in vitro experiment. [Abstract]2023 Dec 15;102(50):e36177. PMID: 38115276 -
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Biomed Pharmacother
Caffeic acid mitigates myocardial fibrosis and improves heart function in post-myocardial infarction by inhibiting transforming growth factor-β receptor 1 signaling pathways. [Abstract]2024 Aug:177:117012. PMID: 38906025
Reinheit & Dokumentation
Verweise
[1]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268. [Content Brief]
[2]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35. [Content Brief]
[3]. Li N, et al. Simplified captopril analogues as NDM-1 inhibitors. Bioorg Med Chem Lett. 2014;24(1):386-389. [Content Brief]
[4]. Tzakos, A.G., et al., The molecular basis for the selection of captopril cis and trans conformations by angiotensin I converting enzyme. Bioorg Med Chem Lett, 2006. 16(19): p. 5084-7. [Content Brief]
[5]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24. [Content Brief]
Calculators
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Captopril hydrochloride Related Classifications
HY-B0368A Related Classifications
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