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Art. -Nr.: HY-B0102D

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Fluoxetine oxalate

(Synonyms: LY-110140 oxalate)

34 Cited Publications

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Based on 34 publication(s) in Google Scholar

Fluoxetine oxalate is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

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CAS. Nr.: 114414-02-7
Formel: C₁₉H₂₀F₃NO₅
Molecular Weight:399.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Fluoxetine oxalate Chemical Structure

CAS. Nr.: 114414-02-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

Fluoxetine oxalate is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

Chemical Information

CAS. Nr. 114414-02-7
Molecular Weight 399.36
Formel C₁₉H₂₀F₃NO₅
SMILES

O=C(C(O)=O)O.FC(F)(C1=CC=C(C=C1)OC(CCNC)C2=CC=CC=C2)F
Synonyms

LY-110140 oxalate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (34)

All In Vivo ImagingIHCIn Vivo Efficacy StudyWB

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Journal Impact Factor

Nat Med

Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity. [Abstract]

2019 Sep;25(9):1428-1441. PMID: 31501614
Cell Metab

Serotonin-licensed macrophages potentiate chemoresistance via inositol metabolic crosstalk in ovarian cancer. [Abstract]

2025 Dec 17:S1550-4131(25)00495-4. PMID: 41412121

Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]

Ovarian cancer ID8 syngeneic model testing fluoxetine effect, Fluoxetine treatment (20 mg/kg over drinking water starting 7 days before first chemotherapy and continued until harvest), Cisplatin (5 mg/kg, twice/week, intraperitoneal injection in indicated time windows). The figure shows representative bioluminescence imaging results.

Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]

Fluoxetine (20 mg/kg over drinking water starting 7 days before first chemotherapy and continued until harvest). Ovarian cancer PDX #1795 mouse model treated with PARPi (Olaparib) alone or with a combination of Fluoxetine.
Nat Commun

Targeting dopamine transporter for treating social transmission of depression-like behaviors in male mice. [Abstract]

2026 Jun 16. PMID: 42303982
Adv Sci (Weinh)

The GRK2/AP-1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress. [Abstract]

2025 Sep;12(33):e01981. PMID: 40492401
J Transl Med

ML335 inhibits TWIK2 channel-mediated potassium efflux and attenuates mitochondrial damage in MSU crystal-induced inflammation. [Abstract]

2024 Aug 22;22(1):785. PMID: 39175013
Mol Med

The role of Dymeclin in chronic unpredictable mild stress-induced depression: maintaining the Golgi apparatus structure and regulating NLRP3 inflammasome activation. [Abstract]

2026 Jun 13. PMID: 42288765
Cell Rep

Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. [Abstract]

2021 Nov 2;37(5):109957. PMID: 34731610
Cell Prolif

Direct inhibitory effect on viral entry of influenza A and SARS-CoV-2 viruses by azithromycin. [Abstract]

2021 Jan;54(1):e12953. PMID: 33211371
Brain Behav Immun

Depression-related chronic stress promotes ovarian cancer progression via metabolic dysfunction and IRF1-mediated immune suppression. [Abstract]

2026 Jan 26:134:106471. PMID: 41605304
Brain Behav Immun

Expression of Cntn1 is regulated by stress and associated with anxiety and depression phenotypes. [Abstract]

2021 Jul:95:142-153. PMID: 33737174

Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]

Fluoxetine (20 mg/kg; ip). Representative images of DCX positive cells in the DG of hippocampus in different group.

Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]

Fluoxetine (20 mg/kg; ip). Representative immunoblots of DCX and NeuN expression levels in different groups.
J Med Chem

Development of Novel Estradiol-Indole Hybrids Targeting SERT and ERβ as Potential Antidepressants. [Abstract]

2026 Jun 11;69(11):13618-13634. PMID: 42154662
Biochem Pharmacol

Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms. [Abstract]

2023 Nov:217:115846. PMID: 37804870
Foods

Fermented Dendrobium officinale Ameliorates Sleep Deprivation-Induced Depressive-like Behaviors by Attenuating Neuroinflammation and Restoring 5-HT Synthesis via the Gut-Brain Axis. [Abstract]

2026 Jun 21;15(12):2237. PMID: 42354205
Eur J Pharmacol

Chronic co-treatment with geniposide and shanzhiside methyl ester elicits antidepressant effects via PACAP signaling in stressed male mice. [Abstract]

2026 Mar 28:1019:178713. PMID: 41794274
Eur J Pharmacol

Gypenoside XVII regulates apoptosis and fear extinction deficits mediated by post-traumatic stress disorder through the PERK/CHOP signaling pathway. [Abstract]

2025 Dec 15:1009:178391. PMID: 41276105
Eur J Pharmacol

SMIP004: A compound with antidepressant-like activities in mouse models. [Abstract]

2019 Jan 15:843:260-267. PMID: 30502341
Biomedicines

Two-Pore-Domain Potassium Channel TREK-1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation. [Abstract]

2023 Apr 26;11(5):1279. PMID: 37238950
Prog Neuropsychopharmacol Biol Psychiatry

Harmine produces antidepressant-like effects via restoration of astrocytic functions. [Abstract]

2017 Oct 3;79(Pt B):258-267. PMID: 28625859

Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):258-267. [Abstract]

Representative images showing the restoration effect of harmine on CUS-induced decrease in hippocampal DCX protein expressions. The Fluoxetine administration (20 mg/kg; ip) was used as a positive control, and all data were shown as mean ± SEM.
Virol J

KCNE4 is a crucial host factor for Orf virus infection by mediating viral entry. [Abstract]

2024 Aug 8;21(1):181. PMID: 39118175
J Psychiatr Res

Acquisition and extinction of active avoidance compulsive-like behavior in mice. [Abstract]

2023 Oct 19:168:91-99. PMID: 39492237
Reprod Toxicol

Long-term Oral Fluoxetine Leads to Reduced Male Reproductive Function in Mice and Gradual Recovery After Discontinuation. [Abstract]

2025 Mar:132:108840. PMID: 39826770
Chem Biodivers

New 2,3-Methylenedioxy-naphthalene Derivatives With Neuroprotective Activity From the Roots of Ephedra sinica Stapf. [Abstract]

2025 Sep 24:e00918. PMID: 40991575
J Clin Psychopharmacol

Citalopram and Cannabidiol: In Vitro and In Vivo Evidence of Pharmacokinetic Interactions Relevant to the Treatment of Anxiety Disorders in Young People. [Abstract]

2021 Sep-Oct;41(5):525-533. PMID: 34121064
Behav Brain Res

Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine?. [Abstract]

2017 Jan 15:317:62-70. PMID: 27633560
Biochem Biophys Res Commun

Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]

2020 Feb 19;522(4):862-868. PMID: 31806372
Behav Pharmacol

Hesperidin produces antidepressant effects by activating AMPA receptor: enhancing synaptic proteins to promote hippocampal neuronal activities. [Abstract]

2025 Apr 1;36(2-3):127-136. PMID: 39611623
Behav Pharmacol

NSC689857, an inhibitor of Skp2, produces antidepressant-like effects in mice. [Abstract]

2024 Jun 1;35(4):227-238. PMID: 38651981
Behav Pharmacol

Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice. [Abstract]

2021 Feb 1;32(1):62-72. PMID: 33416256
bioRxiv

2026 May 29.
Orebro University

2024.
Research Square Preprint

2024 Dec 16.
Research Square Preprint

2023 Jun 29.
Research Square Preprint

2023 Jun 16.
Chemosphere

Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]

2019 Jun:225:378-387. PMID: 30884299

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71 [Content Brief]

[2]. Avitsur R1. Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine? Behav Brain Res. 2017 Jan 15;317:62-70. [Content Brief]

[3]. Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56(8):570-80. [Content Brief]

[4]. Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28(6):1374-84. [Content Brief]

[5]. Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl). 2002 Apr;160(4):353-61 [Content Brief]

[6]. Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23(3):250-62. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Fluoxetine oxalate

34 Cited Publications

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Biologische Aktivität
- Beschreibung
Chemical Information
Publications (34)
Reinheit & Dokumentation
Verweise

1/16
1/16

Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]

Customer Validation
Ovarian cancer ID8 syngeneic model testing fluoxetine effect, Fluoxetine treatment (20 mg/kg over drinking water starting 7 days before first chemotherapy and continued until harvest), Cisplatin (5 mg/kg, twice/week, intraperitoneal injection in indicated time windows). The figure shows representative bioluminescence imaging results.
1/16

Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]

Customer Validation
Fluoxetine (20 mg/kg over drinking water starting 7 days before first chemotherapy and continued until harvest). Ovarian cancer PDX #1795 mouse model treated with PARPi (Olaparib) alone or with a combination of Fluoxetine.
1/16

Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]

Customer Validation
Fluoxetine (20 mg/kg; ip). Representative images of DCX positive cells in the DG of hippocampus in different group.
1/16

Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]

Customer Validation
Fluoxetine (20 mg/kg; ip). Representative immunoblots of DCX and NeuN expression levels in different groups.
1/16

Fluoxetine oxalate purchased from MedChemExpress. Usage Cited in: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):258-267. [Abstract]

Customer Validation
Representative images showing the restoration effect of harmine on CUS-induced decrease in hippocampal DCX protein expressions. The Fluoxetine administration (20 mg/kg; ip) was used as a positive control, and all data were shown as mean ± SEM.

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Fluoxetine oxalate

Publications Citing Use of MedChemExpress (MCE) Fluoxetine oxalate

Biologische Aktivität

Chemical Information

Publications (34)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Fluoxetine oxalate Related Classifications

HY-B0102D Related Classifications