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Art. -Nr.: HY-173235

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Galectin-3-IN-6

Galectin-3-IN-6 is a human and murine galectin-3 (Gal-3) inhibitor, with an IC₅₀ of 12 nM against human galectin-3, an IC₅₀ of 12.6 nM against mutant murine galectin-3 (V160A), and a K_d of 13 nM for human galectin-3, as well as oral bioavailability. Galectin-3-IN-6 reduces the levels of liver fibrosis markers type I collagen and α-smooth muscle actin in mouse models of acute liver injury and fibrosis. Galectin-3-IN-6 can be used for the research of acute liver injury and fibrosis.

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CAS. Nr.: 2604662-64-6
Formel: C₂₈H₂₉Cl₂F₃N₄O₆
Molecular Weight:645.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Galectin-3-IN-6 Chemical Structure

CAS. Nr.: 2604662-64-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Galectin-3

12 nM (IC₅₀)

Galectin-3

13 nM (Kd)

Alle Galectin Isoform-spezifische Produkte anzeigen :

In Vitro

Galectin-3-IN-6 (compound 12) potently inhibits human galectin-3 in an asialofetuin competitive binding assay with an IC₅₀ of 12 nM^[1].
Galectin-3-IN-6 (compound 12) binds to human galectin-3 with a K_d of 13 nM, as measured by Biacore analysis^[1].
Galectin-3-IN-6 (compound 12) exhibits metabolic stability in human and mouse liver microsomes with intrinsic clearance values of 29 and 20 μL/(min*mg), respectively^[1].
Galectin-3-IN-6 (compound 12) forms a stable complex with human galectin-3, as confirmed by X-ray crystallography (PDB ID: 8RMT), with its hydroxy group replacing the conserved water in the lectin's carbohydrate recognition domain^[1].
Galectin-3-IN-6 (compound 12) binds to V160A mutant mouse galectin-3 with a K_d of 12.6 nM, identical to its inhibitory potency against human galectin-3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	AUC
Mice^[1]	10 mg/kg	p.o.	1540 ng/mL	4460 ng·h/mL
Mice^[1]	100 mg/kg	p.o.	15400 ng/mL	169000 ng·h/mL

In Vivo

Galectin-3-IN-6 (100 mg/kg; p.o.; twice daily) exhibits robust anti-fibrotic activity in a mouse model of acute CCl₄(HY-Y0298)-induced liver injury and fibrosis, producing median reductions of 64% and 71% in collagen-1 and αSMA levels, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 J (homozygous, Gal-3 V160A point mutation)^[1]
Dosage:

100 mg/kg
Administration:

p.o.; twice daily
Result:

Reduced collagen-1 levels by a median of 64%.
Reduced α-smooth muscle actin (αSMA) levels by a median of 71%.

Chemical Information

CAS. Nr. 2604662-64-6
Molecular Weight 645.45
Formel C₂₈H₂₉Cl₂F₃N₄O₆
SMILES

FC1=C(F)C(F)=CC(C2=CN([C@@H]3[C@@H](OC)[C@H](C(N(C4=CC(Cl)=CC(Cl)=C4)[C@@H]5[C@@H](O)CCCC5)=O)O[C@H](CO)[C@@H]3O)N=N2)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zumbrunn C, et al. Discovery of Galactopyranose-1-carboxamides as a New Class of Small, Novel, Potent, Selective, and Orally Active Galectin-3 Inhibitors. ChemMedChem. 2025;20(10):e202401012. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Galectin-3-IN-6

Alle Galectin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Galectin-3-IN-6 Related Classifications

HY-173235 Related Classifications