2604662-64-6
Chemical Structure
Galectin-3-IN-6
- CAS No.: 2604662-64-6
- Formula:C28H29Cl2F3N4O6
- Molecular Weight:645.45
InChIKey: ZGGISKNGKBUFEA-ZSACPDSWSA-N
SMILES: FC1=C(F)C(F)=CC(C2=CN([C@@H]3[C@@H](OC)[C@H](C(N(C4=CC(Cl)=CC(Cl)=C4)[C@@H]5[C@@H](O)CCCC5)=O)O[C@H](CO)[C@@H]3O)N=N2)=C1
Biological Activity: Galectin-3-IN-6 is a human and murine galectin-3 (Gal-3) inhibitor, with an IC50 of 12 nM against human galectin-3, an IC50 of 12.6 nM against mutant murine galectin-3 (V160A), and a Kd of 13 nM for human galectin-3, as well as oral bioavailability. Galectin-3-IN-6 reduces the levels of liver fibrosis markers type I collagen and α-smooth muscle actin in mouse models of acute liver injury and fibrosis. Galectin-3-IN-6 can be used for the research of acute liver injury and fibrosis[1].
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Galectin-3-IN-6 | Galectin-3-IN-6 is a human and murine galectin-3 (Gal-3) inhibitor, with an IC50 of 12 nM against human galectin-3, an IC50 of 12.6 nM against mutant murine galectin-3 (V160A), and a Kd of 13 nM for human galectin-3, as well as oral bioavailability. Galectin-3-IN-6 reduces the levels of liver fibrosis markers type I collagen and α-smooth muscle actin in mouse models of acute liver injury and fibrosis. Galectin-3-IN-6 can be used for the research of acute liver injury and fibrosis. | |||||||||||||||||||||
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Keywords
