DLL3 - delta like canonical Notch ligand 3 Gene

Also Known as SCDO1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10683

About DLL3

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,498,947-39,508,469 (from NCBI)

This gene has 5 transcripts (splice variants), 297 orthologues, 8 paralogues and is associated with 3 phenotypes. Restricted expression toward brain (RPKM 16.1).

Summary

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

DLL3 Products (2)

mRNA	Protein	Name
NM_016941.4	NP_058637.1	delta-like protein 3 isoform 1 precursor
NM_203486.3	NP_982353.1	delta-like protein 3 isoform 2 precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Verweise	Source
involved in skeletal system development	IMP IMP: Inferred from mutant phenotype	10742114	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLL3 Protein Structure

MNNL

hEGF

EGF

hEGF

0
100
200
300
400
500
618 a.a.

Protein Preferred Names	Protein Names
delta-like protein 3	delta-like 3

Recombinant DLL3 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71852	Delta-like protein 3/DLL3 Protein, Human (P.pastoris, His)	Q9NYJ7-1 (A27-L492)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78115	Delta-like protein 3/DLL3 Protein, Human (Biotinylated, HEK293, His)	Q9NYJ7-1 (A27-R490)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700456	Delta-like protein 3/DLL3 Protein, Human (HEK293, His)	Q9NYJ7-1 (A27-L492)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700982	Delta-like protein 3/DLL3 Protein, Human (HEK293, His-Flag)	Q9NYJ7-1 (A27-E215)	≥ 95%, as determined by reducing SDS-PAGE.

DLL3 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P84837	DLL3 Antibody (YA4534)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat
HY-P84837A	DLL3 Antibody (YA4534)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Spondylocostal Dysostosis 1, Autosomal Recessive	Jarcho-Levin Syndrome SCDO1 Vertebral Anomalies Spondylothoracic Dysplasia Costovertebral Dysplasia Spondylothoracic Dysostosis Spondylocostal Dysostosis 1 Autosomal Recessive Spondylocostal Dysostosis 1 Spondylocostal Dysostosis, Autosomal Recessive, 1 Doid:0112365 Dysostosis, Spondylocostal, Autosomal Recessive, Type 1
Spondylocostal Dysostosis, Autosomal Recessive	Autosomal Recessive Spondylocostal Dysostosis Jarcho-Levin Syndrome Costovertebral Dysplasia Spondylocostal Dysplasia Spondylocostal Dysostosis, Autosomal Recessive 2
Leukodystrophy And Acquired Microcephaly With Or Without Dystonia	LDAMD Leukodystrophy And Acquired Microcephaly With Or Without Dystonia
Dysostosis	Dysostoses
Spondylocostal Dysostosis	Jarcho-Levin Syndrome Costovertebral Dysplasia Spondylothoracic Dysostosis Spondylothoracic Dysplasia Scdo Dysostosis, Spondylocostal
Cascade Stomach	Hourglass Stricture Or Stenosis Of Stomach Hourglass Contraction Of Stomach Hourglass Stenosis Of Stomach Hourglass Stricture Of Stomach
Pulmonary Neuroendocrine Tumor	Neuroendocrine Neoplasm Of Lung
Scoliosis
Pulmonary Large Cell Neuroendocrine Carcinoma	Large Cell Lung Neuroendocrine Carcinoma
Gallbladder Small Cell Carcinoma	Oat Cell Carcinoma Of The Gallbladder Gallbladder Small Cell Neuroendocrine Carcinoma
Spondylocostal Dysostosis 4, Autosomal Recessive	SCDO4 Spondylocostal Dysostosis 4 Autosomal Recessive Spondylocostal Dysostosis 4 Doid:0112364 Dysostosis, Spondylocostal, Autosomal Recessive, Type 4
Hajdu-Cheney Syndrome	Acroosteolysis With Osteoporosis And Changes In Skull And Mandible Cheney Syndrome Arthrodentoosteodysplasia HJCYS Serpentine Fibula-Polycystic Kidney Syndrome Sfpks Acroosteolysis Dominant Type Serpentine Fibula-Polycystic Kidneys Syndrome Arthro-Dento-Osteo Dysplasia Cranioskeletal Dysplasia With Acro-Osteolysis Familial Osteodysplasia Hereditary Osteodysplasia With Acro-Osteolysis Hcs Serpentine Fibula Syndrome Acro-Osteolysis Serpentine Fibula Polycystic Kidney Syndrome
Large Cell Neuroendocrine Carcinoma
Alagille Syndrome 1	Alagille Syndrome Arteriohepatic Dysplasia Alagille-Watson Syndrome Cholestasis With Peripheral Pulmonary Stenosis Hepatic Ductular Hypoplasia Alagille Syndrome Due To A Jag1 Point Mutation ALGS1 Algs Aws Syndromic Bile Duct Paucity Cardiovertebral Syndrome Hepatofacioneurocardiovertebral Syndrome Paucity Of Interlobular Bile Ducts Watson-Miller Syndrome Alagille Syndrome Due To 20p12 Microdeletion Ahd Hepatic Ductular Hypoplasia, Syndromatic Watson Alagille Syndrome Alagille'S Syndrome Alagille Syndrome Due To Del(20)(P12) Alagille Syndrome Due To Monosomy 20p12 Alagille-Watson Syndrome Due To Monosomy 20p12 Arteriohepatic Dysplasia Due To Monosomy 20p12 Syndromic Bile Duct Paucity Due To Monosomy 20p12 Alagille-Watson Syndrome Due To A Jag1 Point Mutation Arteriohepatic Dysplasia Due To A Jag1 Point Mutation Syndromic Bile Duct Paucity Due To A Jag1 Point Mutation Alagille Syndrome, Type 1
Large Intestine Adenoma	Adenoma Of Large Intestine
Lung Large Cell Carcinoma	Large Cell Carcinoma Of Lung Large Cell Lung Carcinoma Large Cell Lung Cancer
Adams-Oliver Syndrome	Adams Oliver Syndrome Aos Congenital Scalp Defects With Distal Limb Reduction Anomalies Aplasia Cutis Congenita With Terminal Transverse Limb Defects Congenital Scalp Defects With Distal Limb Anomalies Limb, Scalp And Skull Defects Limb Scalp And Skull Defects Absence Defect Of Limbs, Scalp, And Skull
Klippel-Feil Syndrome	Cervical Vertebral Fusion Congenital Dystrophia Brevicollis Cervical Fusion Syndrome Klippel-Feil Deformity Autosomal Dominant Klippel-Feil Syndrome Congenital Synostosis Of Cervical Vertebrae Klippel-Feil And Turner Syndrome Klippel-Feil Deformity, Deafness And Facial Asymmetry Klippel Feil Syndrome Cervical Vertebral Fusion Syndrome Dystrophia Brevicollis Congenita Fusion Of Cervical Vertebrae Kfs Klippel-Feil Sequence Vertebral Cervical Fusion Syndrome Klippel-Feil Syndrome, Autosomal Dominant Klippel-Feil Malformation Isolated Klippel-Feil Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P99575	Tarlatamab	Inhibitor	99.77%	Unkown

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-132257	Rovalpituzumab tesirine	Inhibitor	97.47%	Phase 3

Inhibitory Antibodies (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P99043	Rovalpituzumab	Inhibitor	99.84%	Phase 3
HY-P990932	Obrixtamig	Inhibitor	99.9%	Phase 3
HY-P991731	Alveltamig		99.00%	Phase 3
HY-P990920	Gocatamig	Inhibitor	≥99.0%	Phase 2
HY-P991016	Peluntamig		99.9%	Phase 2
HY-P990981	Clesitamig		99.78%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-W1126504	ETN029	Ligand	99.91%	Unkown
HY-164729	FZ-AD005		97.27%	Unkown
HY-159072	Mal-Val-Ala-PAB-N(SO2Me)-Exatecan		98.84%	Unkown
HY-RS03809	DLL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16720	Dll3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23156	Dll3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990104	Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757)	Inhibitor	99.39%	Unkown
HY-P990896	FZ-A038		99.15%	Unkown
HY-P992148	Zocilurtatug	Inhibitor	99.50%	Unkown
HY-P991173	AMG-119	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DLL3	VGNC	VGNC:61520
Rattus norvegicus	DLL3	RGD	RGD:70953
Canis familiaris	DLL3	VGNC	VGNC:53689
Macaca mulatta	DLL3	VGNC	VGNC:71925
Bos taurus	DLL3	VGNC	VGNC:28095
Mus musculus	DLL3	MGD	MGI:1096877
Others	DLL3	NCBI