Clesitamig
Based on 1 Customer Validation
Clesitamig (ALPS-12) is a trispecific T cell engager with two CD3/CD137 dual-specific Fabs and one DLL3 Fab. Clesitamig engages CD3 and CD137 on T cells to activate and co-stimulate T cells, promoting their proliferation, survival, and antitumor activity. Clesitamig binds to DLL3 on tumor cells for tumor-specific recognition. Clesitamig can be used for the research of small cell lung cancer (SCLC).
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 2930861-48-4
- Molecular Weight:195.836 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Fab-kappa_crossover-IgG1-kappa_tetrekisdisulfide
Human
CD3E & TNFRSF9 & DLL3
Clesitamig successfully engages its targets to activate CD3 and CD137 signaling, as demonstrated by a dose-dependent increase in NFAT and NF-κB activity in Jurkat reporter cells cocultured with DLL3-positive cells[2].
Clesitamig induces cytotoxicity against SCLC cell lines co-cultured with human PBMCs, with EC50 values in the two-digit picomolar range[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Fab-kappa_crossover-IgG1-kappa_tetrekisdisulfide
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2930861-48-4
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Appearance Liquid
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Molecular Weight 195.836 kDa
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Color Colorless to light yellow
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SMILES
[Clesitamig]
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Synonyms
ALPS-12; RG-6524; RO 7616789
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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