TBP - TATA-box binding protein Gene

Also Known as HDL4; TBP1; GTF2D; SCA17; TFIID; GTF2D1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6908

About TBP

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:170,554,369-170,572,859 (from NCBI)

This gene has 7 transcripts (splice variants), 217 orthologues, 2 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 21.7), lymph node (RPKM 7.6) and 24 other tissues.

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]

TBP Products (2)

mRNA	Protein	Name
NM_001172085.2	NP_001165556.1	TATA-box-binding protein isoform 2
NM_003194.5	NP_003185.1	TATA-box-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	9722567	GOA
enables RNA polymerase I core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11250903	GOA
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	29111974	GOA
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	9841876	GOA
enables RNA polymerase II general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	7724559	GOA
enables RNA polymerase III general transcription initiation factor activity	IMP IMP: Inferred from mutant phenotype	26638071	GOA
enables TFIIB-class transcription factor binding	IPI IPI: Inferred from physical interaction	9841876	GOA
enables aryl hydrocarbon receptor binding	IPI IPI: Inferred from physical interaction	15641800	GOA
enables core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9841876	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	25336585	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1465435	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	7933101	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in RNA polymerase II preinitiation complex assembly	IDA IDA: Inferred from direct assay	9841876	GOA
involved in RNA polymerase II preinitiation complex assembly	IPI IPI: Inferred from physical interaction	27007846	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7724559	GOA
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	27193682	GOA
acts upstream of or within transcription by RNA polymerase III	IDA IDA: Inferred from direct assay	9027316	GOA
involved in transcription by RNA polymerase III	IMP IMP: Inferred from mutant phenotype	26638071	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of RNA polymerase transcription factor SL1 complex	IDA IDA: Inferred from direct assay	11250903	GOA
located in chromatin	IDA IDA: Inferred from direct assay	24289924	GOA
located in euchromatin	IDA IDA: Inferred from direct assay	19861239	GOA
located in nucleus	EXP EXP: Inferred from Experiment	23332750	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9841876	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15641800	GOA
part of transcription factor TFIIA complex	IDA IDA: Inferred from direct assay	7724559	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	7729427	GOA
part of transcription factor TFIID complex	IPI IPI: Inferred from physical interaction	23332750	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBP Protein Structure

TBP

0
100
200
300
339 a.a.

Protein Preferred Names	Protein Names
TATA-box-binding protein	TATA sequence-binding protein

TBP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TBP	P20226	TAF12	Homo sapiens	Q16514	Anti Tag CoIP	17158164
Intra	TBP	P20226	TAF12	Homo sapiens	Q16514	Anti Bait CoIP	9603525
Intra	TBP	P20226	TAF12	Homo sapiens	Q16514	Anti Tag CoIP	35271311
Intra	TBP	P20226	TAF12	Homo sapiens	Q16514	Pull Down	17268553
Intra	TBP	P20226	SET	Homo sapiens	Q01105	Anti Bait CoIP	17318177
Intra	TBP	P20226	SET	Homo sapiens	Q01105	Anti Tag CoIP	17318177
Intra	TBP	P20226	SET	Homo sapiens	Q01105	Pull Down	17318177
Intra	TBP	P20226	POU3F2	Homo sapiens	P20265	Pull Down	11029584
Intra	TBP	P20226	POU3F2	Homo sapiens	P20265	Y2H	11029584
Cross	TBP	P20226	ORF6	Equid herpesvirus 1	L8B1Q7	Pull Down	24418534
Cross	TBP	P20226	ORF6	Equid herpesvirus 1	L8B1Q7	Anti Bait CoIP	24418534
Cross	TBP	P20226	ICP0	Equid herpesvirus 1	P87662	Pull Down	12552007
Intra	TBP	P20226	TAF1B	Homo sapiens	Q53T94	Anti Tag CoIP	26496610
Intra	TBP	P20226	TAF1B	Homo sapiens	Q53T94	Anti Tag CoIP	35271311
Intra	TBP	P20226	TAF1B	Homo sapiens	Q53T94	Anti Tag CoIP	17318177
Cross	TBP	P20226	Cdx1	Mus musculus	P18111	Anti Tag CoIP	17158164
Cross	TBP	P20226	Cdx1	Mus musculus	P18111	Pull Down	17158164
Intra	TBP	P20226	TAF1A	Homo sapiens	Q15573	Anti Tag CoIP	35271311
Intra	TBP	P20226	TAF1A	Homo sapiens	Q15573	Anti Tag CoIP	26496610
Intra	TBP	P20226	TAF1C	Homo sapiens	Q15572	Affinity Chrom	17318177
Intra	TBP	P20226	TP53	Homo sapiens	P04637	Far-WB	7799929
Intra	TBP	P20226	GTF2A1	Homo sapiens	P52655	Anti Tag CoIP	35271311
Intra	TBP	P20226	GTF2A1	Homo sapiens	P52655	Biochemical	8006019
Intra	TBP	P20226	GTF2B	Homo sapiens	Q00403	Biochemical	8006019
Intra	TBP	P20226	TAF1	Homo sapiens	P21675	Far-WB	7680771
Intra	TBP	P20226	TAF1	Homo sapiens	P21675	Anti Bait CoIP	9674425
Intra	TBP	P20226	TAF1	Homo sapiens	P21675	Y2H	7680771
Intra	TBP	P20226	TAF1	Homo sapiens	P21675	Anti Bait CoIP	7680771
Intra	TBP	P20226	TAF1	Homo sapiens	P21675	Anti Bait CoIP	9603525
Intra	TBP	P20226	TAF1	Homo sapiens	P21675	Anti Tag CoIP	35271311
Intra	TBP	P20226	TAF1	Homo sapiens	P21675	Anti Bait CoIP	17884155
Intra	TBP	P20226	EDF1	Homo sapiens	O60869-1	Pull Down	10567391
Intra	TBP	P20226	BRF1	Homo sapiens	Q92994	Anti Tag CoIP	26496610
Intra	TBP	P20226	BRF1	Homo sapiens	Q92994	Y2H	16713569
Intra	TBP	P20226	BRF1	Homo sapiens	Q92994	Anti Tag CoIP	35271311
Cross	TBP	P20226	Su(H)	Drosophila melanogaster	P28159	Anti Bait CoIP	21653638

Cross: Cross-species interaction Intra: Intraspecies interaction

TBP Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83515	TATA Box Binding Protein Antibody (YA3260)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
HY-P83515A	TATA Box Binding Protein Antibody (YA3260)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
HY-P84165	TATA Box Binding Protein Antibody (YA3862)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84165A	TATA Box Binding Protein Antibody (YA3862)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P85743	TATA Box Binding Protein Antibody (YA5435)	WB	Human, Rat, Mouse
HY-P86585	TATA Box Binding Protein Antibody (YA6277)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 17	Spinocerebellar Ataxia Type 17 SCA17 Huntington Disease-Like 4 Hdl4 Olivopontocerebellar Atrophy V Cerebelloparenchymal Disorder Ii Opca5 Cpd2 Sca 17 Ataxia, Spinocerebellar, Type 17
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Dentatorubral-Pallidoluysian Atrophy	DRPLA Naito-Oyanagi Disease Haw River Syndrome Myoclonic Epilepsy With Choreoathetosis Nod Ataxia, Chorea, Seizures, And Dementia Dentatorubropallidoluysian Atrophy Hrs Naito Oyanagi Disease Dentatorubral Pallidoluysian Atrophy Dentatorubro-Pallidoluysian Atrophy Myoclonic Epilepsies, Progressive Atrophy, Pallidoluysian, Dentatorubral
Gastrointestinal Tuberculosis	Tuberculosis Of Intestines, Peritoneum And Mesenteric Glands Tuberculosis, Gastrointestinal Tuberculosis Of Gastrointestinal Tract Tuberculosis Of Intestines, Peritoneum, And Mesenteric Glands
Pericardial Tuberculosis	Pericarditis, Tuberculous Tuberculous Pericarditis Pericarditis Tuberculous
Tuberculous Peritonitis	Peritonitis, Tuberculous Peritonitis Tuberculous
Spinocerebellar Ataxia 12	Spinocerebellar Ataxia Type 12 SCA12 Ataxia, Spinocerebellar, Type 12
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Hereditary Ataxia	Sca Spinocerebellar Ataxia Ataxias Hereditary Ataxias, Hereditary
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Abdominal Tuberculosis
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Extrapulmonary Tuberculosis	EPTB Tuberculosis, Extrapulmonary
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Huntington Disease-Like 1	HDL1 Huntington-Like Neurodegenerative Disorder 1 Hln1 Huntington'S Disease-Like 1 Early-Onset Prion Disease With Prominent Psychiatric Features Huntington-Like Neurodegenerative Disorder, Autosomal Dominant Prion Disease, Early-Onset, With Prominent Psychiatric Features Autosomal Dominant Huntington-Like Neurodegenerative Disorder Huntington Disease-Like, Type 1
Spinal And Bulbar Muscular Atrophy, X-Linked 1	Kennedy Disease Sbma Spinal And Bulbar Muscular Atrophy Kennedy'S Disease X-Linked Spinal And Bulbar Muscular Atrophy SMAX1 Kd Kennedy Spinal And Bulbar Muscular Atrophy Spinobulbar Muscular Atrophy Bulbospinal Muscular Atrophy, X-Linked Bulbospinal Neuronopathy, X-Linked Recessive Xbsn Spinal And Bulbar Muscular Atrophy Of Kennedy Bulbospinal Muscular Atrophy X-Linked Bulbospinal Amyotrophy Bulbo-Spinal Atrophy, X-Linked Spinal Bulbar Muscular Atrophy X-Linked Bulbo-Spinal Atrophy X-Linked Spinal Bulbar Muscular Atrophy X-Linked Bsma X-Linked Bulbospinal Muscular Atrophy Spinal And Bulbar Muscular Atrophy X-Linked 1 Bulbospinal Muscular Atrophy X-Linked Bulbospinal Neuronopathy X-Linked Recessive Kennedy Disease) Kennedy Syndrome Atrophy, Muscular, Spinal And Bulbar, Kennedy Type Atrophy, Muscular, Spinobulbar Bulbospinal Neuronopathy
Friedreich Ataxia	Friedreich Ataxia 1 FRDA Friedreich Ataxia With Retained Reflexes Frda1 Fa Friedreich'S Ataxia Hereditary Spinal Ataxia Fa1 Friedreich'S Tabes Hereditary Spinal Sclerosis Spinocerebellar Ataxia, Friedreich Friedreich Spinocerebellar Ataxia Friedrich'S Ataxia
Glioblastoma Classical Subtype
Pleural Tuberculosis	Pearly Disease Tuberculosis Of Pleura Tuberculous Pleurisy Tuberculous Pleurisy In Primary Progressive Tuberculosis Tuberculous Pleuritis Pleurisy Tuberculous Tuberculosis, Pleural Serosal Tuberculosis Of Cattle
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Neuroacanthocytosis	Neuroacanthocytosis Syndrome
Cerebellar Ataxia Type 48	Sca48
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Choreatic Disease	Chorea Hereditary Chorea
Dystonia 3, Torsion, X-Linked	X-Linked Dystonia-Parkinsonism DYT3 Xdp Lubag Dystonia-Parkinsonism, X-Linked Torsion Dystonia-Parkinsonism, Filipino Type Dyt-Taf1 X-Linked Dystonia-Parkinsonism Syndrome X-Linked Torsion Dystonia-Parkinsonism Syndrome Dystonia Musculorum Deformans X-Linked Dystonia-Parkinsonism/Lubag Lubag Syndrome Dystonia-3 Torsion Dystonia-Parkinsonism Filipino Type X-Linked Torsion Dystonia 3 Dystonia, Torsion, X-Linked, Type 3
Olivopontocerebellar Atrophy	Thomas Syndrome Olivopontocerebellar Atrophies Dejerine-Thomas Syndrome Thomas' Syndrome Wadia-Swami Syndrome Opca Potter Sequence-Cleft Lip/Palate-Cardiopathy Syndrome Spinocerebellar Ataxia Type 2
Choreoacanthocytosis	Chorea-Acanthocytosis CHAC Acanthocytosis With Neurologic Disorder Levine-Critchley Syndrome Choreaacanthocytosis Chorea Acanthocytosis Neuroacanthocytosis Levine-Critchley Syndrome, Formerly Neuroacanthocytosis, Formerly Choreo-Acanthocytosis Acanthocytosis Chorea Chorea Acanthocytosis Syndrome
Theileriasis	Theileriosis Infection By Theileria
Huntington Disease-Like 2	HDL2 Huntington'S Disease-Like 2 Huntington Disease-Like, Type 2
Tick Infestation	Tick Infestations
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Spinocerebellar Ataxia 1	Spinocerebellar Ataxia Type 1 SCA1 Olivopontocerebellar Atrophy I Opca1 Opca4 Menzel Type Opca Schut-Haymaker Type Opca Spinocerebellar Atrophy I Opca I Olivopontocerebellar Atrophy Iv Opca Iv Cerebelloparenchymal Disorder I Cpd1 Olivopontocerebellar Atrophy 1 Cerebelloparenchymal Disorder 1 Olivopontocerebellar Atrophy 4 Spinocerebellar Atrophy 1 Type 1 Spinocerebellar Ataxia Spinocerebellar Ataxia-1 Ataxia, Spinocerebellar, Type 1
Retinal Degeneration	Degeneration Of Retina
Spinocerebellar Ataxia 6	Spinocerebellar Ataxia Type 6 SCA6 Type 6 Spinocerebellar Ataxia Spinocerebellar Ataxia-6 Ataxia, Spinocerebellar, Type 6
Human Granulocytic Anaplasmosis	Human Granulocytic Ehrlichiosis Hge Human Ehrlichial Infection, Human Granulocytic Type Human Anaplasmosis Due To Anaplasma Phagocytophilum
Spinocerebellar Ataxia 40	Spinocerebellar Ataxia Type 40 SCA40 Ataxia, Spinocerebellar, Type 40
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Episodic Ataxia	Isaacs Syndrome Neuromyotonia Isaacs' Syndrome Acquired Neuromyotonia Continuous Muscle Fiber Activity Syndrome Quantal Squander Syndrome Isaacs-Mertens Syndrome Ea Syndrome Episodic Ataxia Syndrome Isaac Syndrome Isaac'S-Merten'S Syndrome Isaac-Mertens Syndrome Peripheral Nerve Hyperexcitability Ea Peripheral Nerve Hyperexcitability Syndrome Ataxia, Episodic Isaacs Neuromyotonia Continuous Muscle Fibre Activity
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Movement Disease	Movement Disorders Movement Disorder
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-16579A	Etifoxine	Activator	99.27%	Phase 3
HY-105056	Bretazenil	Agonist	99.13%	Phase 3
HY-16579	Etifoxine hydrochloride	Activator	99.83%	Phase 3

Pre-clinical Phase

Bioactive Molecules (7)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-105567A	Carbiphene hydrochloride	Antagonist	/	Unkown
HY-114811	Leptophos oxon	Inhibitor	/	Unkown
HY-172940	TBP-134	Inducer	/	Unkown
HY-RS14266	TBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-105567	Carbiphene	Antagonist	/	Unkown
HY-RS18225	Tbp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24702	Tbp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TBP	VGNC	VGNC:47164
Rattus norvegicus	TBP	RGD	RGD:67398
Mus musculus	TBP	MGD	MGI:101838
Felis catus	TBP	VGNC	VGNC:97656
Macaca mulatta	TBP	VGNC	VGNC:78110
Others	TBP	NCBI