TAF1B - TATA-box binding protein associated factor, RNA polymerase I subunit B Gene

Also Known as SL1; RAF1B; RAFI63; TAFI63; MGC:9349

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9014

Summary

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Ubiquitous expression in testis (RPKM 5.9), placenta (RPKM 5.4) and 25 other tissues.

TAF1B Products (3)

mRNA Protein Name
NM_001318976.1 NP_001305905.1 TATA box-binding protein-associated factor RNA polymerase I subunit B isoform b
NM_001318977.1 NP_001305906.1 TATA box-binding protein-associated factor RNA polymerase I subunit B isoform b
NM_005680.3 NP_005671.3 TATA box-binding protein-associated factor RNA polymerase I subunit B isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables RNA polymerase I core promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21921198 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11250903 GOA
Biological Process GO Annotation Evidence Références Source
involved in RNA polymerase I preinitiation complex assembly IDA
IDA: Inferred from direct assay
21921199 GOA
Cellular Component GO Annotation Evidence Références Source
part of RNA polymerase I core factor complex IDA
IDA: Inferred from direct assay
21921198 GOA
part of RNA polymerase transcription factor SL1 complex IDA
IDA: Inferred from direct assay
11250903 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TAF1B Q53T94 SET Homo sapiens Q01105
Anti Tag CoIP
17318177
Intra
TAF1B Q53T94 SET Homo sapiens Q01105
Pull Down
17318177
Intra
TAF1B Q53T94 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
TAF1B Q53T94 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
TAF1B Q53T94 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
TAF1B Q53T94 TAF1A Homo sapiens Q15573
Anti Tag CoIP
33961781
Intra
TAF1B Q53T94 TBP Homo sapiens P20226
Pull Down
17318177
Intra
TAF1B Q53T94 TBP Homo sapiens P20226
Affinity Chrom
17318177
Intra
TAF1B Q53T94 ACADVL Homo sapiens P49748
Y2H Array
32296183
Intra
TAF1B Q53T94 ACADVL Homo sapiens P49748
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS16492 TAF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22842 Taf1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29357 Taf1b Rat Pre-designed siRNA Set A / Unkown