SET - SET nuclear proto-oncogene Gene

Also Known as 2PP2A; IGAAD; MRD58; TAF-I; I2PP2A; IPP2A2; PHAPII; TAF-IBETA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6418

About SET

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,683,424-128,696,396 (from NCBI)

This gene has 14 transcripts (splice variants), 285 orthologues, 18 paralogues and is associated with 50 phenotypes. Ubiquitous expression in lymph node (RPKM 55.8), appendix (RPKM 46.5) and 25 other tissues.

Summary

The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits Apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SET Products (5)

mRNA Protein Name
NM_001122821.2 NP_001116293.1 protein SET isoform 1
NM_001248000.2 NP_001234929.1 protein SET isoform 3
NM_001248001.2 NP_001234930.1 protein SET isoform 4
NM_001374326.1 NP_001361255.1 protein SET isoform 1
NM_003011.4 NP_003002.2 protein SET isoform 2
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11909973 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19343227 GOA
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
18374643 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11909973 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
11555662 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11555662 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11555662 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
11909973 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SET Protein Structure

NAP

NAP: Nucleosome assembly protein (NAP) (43 - 235)

  • 0
  • 100
  • 200
  • 290 a.a.
Protein Preferred Names Protein Names

protein SET

  • HLA-DR-associated protein II

SET Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SET Q01105 FOXO1 Homo sapiens Q12778 24983498
Intra
SET Q01105 FOXO1 Homo sapiens Q12778 24983498
Intra
SET Q01105 FOXO1 Homo sapiens Q12778 24983498
Intra
SET Q01105 TAF1B Homo sapiens Q53T94 17318177
Intra
SET Q01105 TAF1C Homo sapiens Q15572 17318177
Intra
SET Q01105 TBP Homo sapiens P20226 17318177
Intra
SET Q01105 MDM2 Homo sapiens Q00987 20195357
Intra
SET Q01105 UBTF Homo sapiens P17480 17318177
Intra
SET Q01105 RAC1 Homo sapiens P63000 17245428
Intra
SET Q01105 RAC1 Homo sapiens P63000 17245428
Intra
SET Q01105 PRKAR1A Homo sapiens P10644
TAP
20195357
Intra
SET Q01105 FAM111B Homo sapiens Q6SJ93 33961781
Intra
SET Q01105 SDCBP Homo sapiens O00560 25416956
Intra
SET Q01105 SDCBP Homo sapiens O00560 25416956
Intra
SET Q01105 SDCBP Homo sapiens O00560 25416956
Intra
SET Q01105 THAP7 Homo sapiens Q9BT49 31515488
Intra
SET Q01105 THAP7 Homo sapiens Q9BT49 25416956
Intra
SET Q01105 THAP7 Homo sapiens Q9BT49 25416956
Intra
SET Q01105 THAP7 Homo sapiens Q9BT49 21988832
Intra
SET Q01105 THAP7 Homo sapiens Q9BT49 16189514
Intra
SET Q01105 THAP7 Homo sapiens Q9BT49
Y2H
21988832
Intra
SET Q01105 MEOX2 Homo sapiens P50222 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

SET Antibodies

Cat. No. Product Name Application Reactivity
HY-P82190 SET Antibody (YA1935) WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P82190A SET Antibody (YA1935)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 58
  • Mental Retardation, Autosomal Dominant 58

  • MRD58

Precursor T-Cell Acute Lymphoblastic Leukemia
  • T-All

  • Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

  • Precursor T-Cell Acute Lymphocytic Leukemia

  • Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Adult T-Cell Lymphoma/Leukemia

Autosomal Dominant Non-Syndromic Intellectual Disability
Acute Biphenotypic Leukemia
  • Mixed Phenotype Acute Leukemia

  • Acute Leukemia Of Ambiguous Lineage

  • Acute Undifferentiated Leukemia

  • Acute Leukemia Of Indeterminate Lineage

  • Hybrid Acute Leukemia

  • Mixed Lineage Acute Leukemia

  • All With Myeloid Markers

  • Aml With Lymphoid Markers

  • Acute Leukemia Of Undetermined Lineage

  • Bal

  • Biphenotypic Acute Leukemia

  • Undifferentiated Acute Leukemia

  • Mpal

  • Acute Myeloid Leukemia, Minimal Differentiation, Fab M0

  • Leukemia, Biphenotypic, Acute

Leukemia
  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus SET MGD MGI:1860267
Rattus norvegicus SET RGD RGD:41368318
Others SET NCBI