TAF1A - TATA-box binding protein associated factor, RNA polymerase I subunit A Gene

Homo sapiens

Also known as SL1; RAFI48; TAFI48; MGC:17061

Gene ID: 9015 | Gene type: protein coding

About TAF1A

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:222,554,105-222,589,933 (from NCBI)

This gene has 7 transcripts (splice variants), 201 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 2.3), lymph node (RPKM 1.9) and 24 other tissues.

Summary

This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]

TAF1A Products(3)

mRNA	Protein	Name
NM_001201536.1	NP_001188465.1	TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1
NM_005681.4	NP_005672.1	TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1
NM_139352.2	NP_647603.1	TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2

TAF1A Protein Structure

TAF1_subA

0
100
200
300
400
450 a.a.

Protein Preferred Names

Protein Names

TATA box-binding protein-associated factor RNA polymerase I subunit A

RNA polymerase I-specific TBP-associated factor 48 kDa

Related Diseases

Diseases

Alias

Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Alopecia, Neurologic Defects, And Endocrinopathy Syndrome

Ane Syndrome	ANES
Alopecia-Progressive Neurological Defect-Endocrinopathy Syndrome	Alopecia-Progressive Neurological Defect-Endocrinopathy
Endocrine System Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14163	TAF1A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TAF1A	VGNC	VGNC:35569
Felis catus	TAF1A	VGNC	VGNC:65927
Macaca mulatta	TAF1A	VGNC	VGNC:78087
Canis familiaris	TAF1A	VGNC	VGNC:47077
Mus musculus	TAF1A	MGD	MGI:109578
Rattus norvegicus	TAF1A	RGD	RGD:1305698

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