Harzianic acid
Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide.
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- CAS. Nr.: 157148-06-6
- Formel: C19H27NO6
- Molecular Weight:365.42
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Acetohydroxyacid synthase (AHAS)[2]
Harzianic acid shows significant antimicrobial activity against MRSP and MSSP, with MIC values of 32 μg/mL and 16 μg/mL, respectively[1].
Harzianic acid (8-128 μg/mL) exhibits low cytotoxicity on HaCaT cells[1].
Harzianic acid inhibits fungal ThAHAS as a competitive inhibitor with a Ki of 6.65 μM[2].
Harzianic acid (0.1-100 μg/mL) inhibits pathogenic fungi growth[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 157148-06-6
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Molecular Weight 365.42
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Formel C19H27NO6
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SMILES
CC(C)[C@@](C(O)=O)(O)C[C@H](N1C)C(/C(C1=O)=C(O)\C=C\C=C\CCC)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. De Filippis A, et al. Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius. Nat Prod Res. 2021 Dec;35(23):5440-5445. [Content Brief]
[2]. Xie L, et al. Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase. J Am Chem Soc. 2021 Jun 16:10.1021/jacs.1c03988. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Harzianic acid Related Classifications
HY-122950 Related Classifications
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