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Art. -Nr.: HY-13017S

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Ivacaftor-d₉

(Synonyms: VX-770-d₉)

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

Ivacaftor-d₉ is a potent CFTR modulator and exhibits an EC₅₀ value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.79%
CAS. Nr.: 1413431-07-8
Formel: C₂₄H₁₉D₉N₂O₃
Molecular Weight:401.55

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ivacaftor-d₉ Chemical Structure

CAS. Nr.: 1413431-07-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
- Clinical Trial
- Anwendung
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters C_max, AUC_{0-24 hr}, C_24hr and t_1/2 of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.
CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters C_max, AUC_{0-24 hr}, C_24hr and t_1/2 of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS. Nr. 1413431-07-8
Unlabeled Cas 873054-44-5
Appearance Solid
Molecular Weight 401.55
Formel C₂₄H₁₉D₉N₂O₃
Color White to off-white
SMILES

CC(C)(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(C=C1NC(C2=CNC(C=CC=C3)=C3C2=O)=O)O)C
Synonyms

VX-770-d₉
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

bioRxiv

Profiling the CFTR Variant Selectivity and Off-Target Interactions of VX-121. [Abstract]

2026 Jun 8:2026.06.01.729306. PMID: 42282787

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (124.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4904 mL

12.4517 mL

24.9035 mL

5 mM

0.4981 mL

2.4903 mL

4.9807 mL

10 mM

0.2490 mL

1.2452 mL

2.4903 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4903 mL	12.4517 mL	24.9035 mL	62.2587 mL
	5 mM	0.4981 mL	2.4903 mL	4.9807 mL	12.4517 mL
	10 mM	0.2490 mL	1.2452 mL	2.4903 mL	6.2259 mL
	15 mM	0.1660 mL	0.8301 mL	1.6602 mL	4.1506 mL
	20 mM	0.1245 mL	0.6226 mL	1.2452 mL	3.1129 mL
	25 mM	0.0996 mL	0.4981 mL	0.9961 mL	2.4903 mL
	30 mM	0.0830 mL	0.4151 mL	0.8301 mL	2.0753 mL
	40 mM	0.0623 mL	0.3113 mL	0.6226 mL	1.5565 mL
	50 mM	0.0498 mL	0.2490 mL	0.4981 mL	1.2452 mL
	60 mM	0.0415 mL	0.2075 mL	0.4151 mL	1.0376 mL
	80 mM	0.0311 mL	0.1556 mL	0.3113 mL	0.7782 mL
	100 mM	0.0249 mL	0.1245 mL	0.2490 mL	0.6226 mL

Keywords

Ivacaftor-d₉

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vivo
- Clinical Trial
- Anwendung
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Ivacaftor-d9

Publications Citing Use of MedChemExpress (MCE) Ivacaftor-d9

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Ivacaftor-d9 Related Classifications

HY-13017S Related Classifications

Ivacaftor-d₉

Publications Citing Use of MedChemExpress (MCE) Ivacaftor-d₉

Ivacaftor-d₉ Related Classifications