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Art. -Nr.: HY-P11840

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KLK5-IN-1

KLK5-IN-1 is a selective kallikrein 5 (KLK5) inhibitor with an IC₅₀ of 14 nM and a K_i of 11 nM. KLK5-IN-1 reduces KLK5-mediated PAR2-dependent calcium mobilization. KLK5-IN-1 improves epithelial barrier integrity. KLK5-IN-1 can be used in research related to atopic dermatitis and Netherton syndrome.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₆₉H₉₆N₂₀O₂₁S₂
Molecular Weight:1605.75

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

KLK5-IN-1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

KLK5

14 nM (IC₅₀)

PAR2

Alle Kallikrein Isoform-spezifische Produkte anzeigen :

Alle Protease Activated Receptor (PAR) Isoform-spezifische Produkte anzeigen :

In Vitro

KLK5-IN-1 (Compound 7) potently and selectively inhibits purified KLK5 with an IC₅₀ of 14 nM and a K_i of 11 nM, with no activity against KLK7, KLK8, or KLK14 at concentrations above 1 μM^[1].
KLK5-IN-1 (2.5-40 μM; 1 h) dose-dependently inhibits rKLK5-mediated PAR2 activation in N/TERT keratinocytes, with complete inhibition observed at 10 μM^[1].
KLK5-IN-1 (100 nM-10 μM) dose-dependently inhibits elevated endogenous KLK5 activity in NS keratinocytes but has no significant effect on KLK5 activity in healthy donor keratinocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1605.75
Formel C₆₉H₉₆N₂₀O₂₁S₂
Sequence

cyclo(Gly-Phe-Cys-Thr-Arg-Ser-Asn-Pro-Pro-Glu-Cys-Trp-Pro-Asn) (Disulfide bridge: Cys3-Cys11)
Sequence Shortening

cyclo(GFCTRSNPPECWPN) (Disulfide bridge: Cys3-Cys11)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Mah J, et al. LEKTI-Grafted Sunflower Trypsin Inhibitor: A Potential Therapeutic for Skin Diseases. Journal of medicinal chemistry. 2025 Nov 27;68(22):24127-24135. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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KLK5-IN-1

Alle Kallikrein Isoform-spezifische Produkte anzeigen

Alle Protease Activated Receptor (PAR) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

KLK5-IN-1 Related Classifications

HY-P11840 Related Classifications