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Art. -Nr.: HY-W127737

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Methylcobalamin hydrate

(Synonyms: Mecobalamin hydrate)

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

Methylcobalamin Hydrate is a coenzyme required for methionine biosynthesis. Vitamins (hematopoiesis). It acts as a histamine receptor, Alzheimer study. Methylcobalamin is also used in the research of peripheral neuropathy, diabetic neuropathy, and as an initial research for amyotrophic lateral sclerosis. It can be used to prevent or research pathologies caused by vitamin B12 deficiency, such as pernicious anemia.

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CAS. Nr.: 288315-09-3
Formel: C₆₃H₉₁CoN₁₃O₁₄P.xH₂O

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (256 KB)

Methylcobalamin hydrate Chemical Structure

CAS. Nr.: 288315-09-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

Chemical Information

CAS. Nr. 288315-09-3
Formel C₆₃H₉₁CoN₁₃O₁₄P.xH₂O
SMILES

[CH3-][Co+3]([N-]1[C@]([C@@H]2CC(N)=O)([H])[C@]3([C@](C)4CC(N)=O)C)([N](C([C@](C)5CC(N)=O)=C6C)=C7[C@H]5CCC(N)=O)([N](C(C(C)8C)=C7)=C([C@H]8CCC(N)=O)C(C)=C1[C@@]2(CCC(NC[C@H]9C)=O)C)([N](C%10=C%11)=CN([C@@H](O[C@@H]%12CO)[C@]([C@@H]%12O[P]([O-])(O9)=O)([H])O)C%10=CC(C)=C%11C)[N]3=C6[C@H]4CCC(N)=O.O
Synonyms

Mecobalamin hydrate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (6)

All Bio/Physico-chemical AssayWBCell Imaging/StainingIn Vivo Efficacy Study

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Journal Impact Factor

Nat Commun

Methylcobalamin protects against liver failure via engaging gasdermin E. [Abstract]

2025 Jan 31;16(1):1233. PMID: 39890804

Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

MST measurements of the binding of 0.2 μM recombinant caspase-3, GSDME, GSDMD with Methylcobalamin (MeCbl) or positive control. Methylcobalamin (MeCbl) specifically bound to GSDME but not to caspase-3 or GSDMD.

Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

Representative immunoblot of GSDME pretreated with inhibitors as indicated, and then incubated with recombinant active caspase-3 for GSDME activation analysis. GSDME cleavage by caspase-3 was potently disrupted by Methylcobalamin (MeCbl) (1 μM; 30 min).

Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

Changes in HepG2 cell morphology were observed with a microscope. Methylcobalamin (MeCbl) (20 μM; 2h) obviously blocked the appearance of pyroptotic bubbles (red arrow).

Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

SYTOX fluorescence probe was used to investigate the protective effects of Methylcobalamin (MeCbl) (20 μM) on DCA-induced systemic and liver injury. The liver region was indicated with a red or yellow circle. Methylcobalamin (MeCbl) was effective against DCA-induced liver damage of zebrafish.

Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

Methylcobalamin (MeCbl) (10 mg/kg; i.g.; once daily) treatment drastically reduced Serum transaminase ALT/AST activities, IL-1α and IL-1β in wild-type six-week-old C57BL/6J male mice.
Adv Sci (Weinh)

VDLIN: A Deep Learning-Based Platform for Methylcobalamin-Inspired Immunomodulatory Compound Screening. [Abstract]

2025 Oct 27:e13775. PMID: 41144841
Phytomedicine

Baohuoside I induces GSDME-dependent pyroptosis and synergistically inhibits lung adenocarcinoma with cisplatin. [Abstract]

2026 Apr:153:157899. PMID: 41643445
Virol Sin

EV-A71 induces GSDME-dependent T-cell pyroptosis: A novel mechanism and MeCbl therapeutic potential. [Abstract]

2026 May 29:S1995-820X(26)00084-2. PMID: 42217583
J Integr Neurosci

Conical Chitosan Conduits Combined With Methylcobalamin for Sciatic Nerve Transposition Repair. [Abstract]

2025 Jun 24;24(6):36965. PMID: 40613369
J Cell Biochem

Methyl B12 protects PC12 cells against cytotoxicity induced by Aβ25-35. [Abstract]

2019 Jul;120(7):11921-11930. PMID: 30793354

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (256 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Keywords

Methylcobalamin hydrate

6 Cited Publications

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Biologische Aktivität
- Beschreibung
Chemical Information
Publications (6)
Reinheit & Dokumentation

1/16
1/16

Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

Customer Validation
MST measurements of the binding of 0.2 μM recombinant caspase-3, GSDME, GSDMD with Methylcobalamin (MeCbl) or positive control. Methylcobalamin (MeCbl) specifically bound to GSDME but not to caspase-3 or GSDMD.
1/16

Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

Customer Validation
Representative immunoblot of GSDME pretreated with inhibitors as indicated, and then incubated with recombinant active caspase-3 for GSDME activation analysis. GSDME cleavage by caspase-3 was potently disrupted by Methylcobalamin (MeCbl) (1 μM; 30 min).
1/16

Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

Customer Validation
Changes in HepG2 cell morphology were observed with a microscope. Methylcobalamin (MeCbl) (20 μM; 2h) obviously blocked the appearance of pyroptotic bubbles (red arrow).
1/16

Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

Customer Validation
SYTOX fluorescence probe was used to investigate the protective effects of Methylcobalamin (MeCbl) (20 μM) on DCA-induced systemic and liver injury. The liver region was indicated with a red or yellow circle. Methylcobalamin (MeCbl) was effective against DCA-induced liver damage of zebrafish.
1/16

Methylcobalamin hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]

Customer Validation
Methylcobalamin (MeCbl) (10 mg/kg; i.g.; once daily) treatment drastically reduced Serum transaminase ALT/AST activities, IL-1α and IL-1β in wild-type six-week-old C57BL/6J male mice.

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Methylcobalamin hydrate

Publications Citing Use of MedChemExpress (MCE) Methylcobalamin hydrate

Biologische Aktivität

Chemical Information

Publications (6)

Reinheit & Dokumentation

Calculators

Help & FAQs

Methylcobalamin hydrate

Publications Citing Use of MedChemExpress (MCE) Methylcobalamin hydrate

Biologische Aktivität

Chemical Information

Publications (6)

Reinheit & Dokumentation

Calculators

Help & FAQs

Methylcobalamin hydrate Related Classifications

HY-W127737 Related Classifications