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Art. -Nr.: HY-10975

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MK-0752 sodium

14 Cited Publications

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Based on 14 publication(s) in Google Scholar

MK-0752 sodium is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC₅₀ of 5 nM in human SH-SY5Y cells. MK-0752 sodium crosses the blood-brain barrier. MK-0752 sodium reduces newly generated CNS Aβ in vivo.

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CAS. Nr.: 656810-87-6
Formel: C₂₁H₂₀ClF₂NaO₄S
Molecular Weight:464.89

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

MK-0752 sodium Chemical Structure

CAS. Nr.: 656810-87-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

Chemical Information

CAS. Nr. 656810-87-6
Molecular Weight 464.89
Formel C₂₁H₂₀ClF₂NaO₄S
SMILES

O=C(CC[C@H]1CC[C@@](C2=CC(F)=CC=C2F)(S(=O)(C3=CC=C(Cl)C=C3)=O)CC1)O[Na]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (14)

All Cell Proliferation/Viability AssayWB

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Journal Impact Factor

Nat Biotechnol

Intravenous administration of blood-brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system. [Abstract]

2024 Nov 25. PMID: 39587229
Nat Mater

Blood-brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. [Abstract]

2025 Feb 17. PMID: 39962245
EMBO Mol Med

γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct. [Abstract]

2017 Jul;9(7):950-966. PMID: 28539479

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966. [Abstract]

IC₅₀ curves of MK-0752 (10^-4-10⁴ nM) on cNOTCHsub.

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966. [Abstract]

Dose responses of cAPPC100sub and full-length APP cleavage to MK-0752 (10^-4-10⁴ nM).

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966. [Abstract]

MK-0752 (100 nM-12.5 μM) strongly decreased NICD levels in the breast cancer line MDA-MB-231.

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966. [Abstract]

MK-0752 (0.5-12.5 μM) inhibited APP-CTF process in MDA-MB-231 cells in a dose-dependent manner.

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966. [Abstract]

Absolute viable cell counts of mammospheres from MDA-MB-231 and MDA-MB-468 cell lines treated with MK-0752 (10 μM; 7 d).
Int J Mol Sci

Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma. [Abstract]

2022 May 26;23(11):5980. PMID: 35682660
Biofactors

ErbB2-NOTCH1 axis controls autophagy in cardiac cells. [Abstract]

2025 Jan-Feb;51(1):e2091. PMID: 38994725
Cancers (Basel)

Combined Treatment of Uterine Leiomyosarcoma with Gamma Secretase Inhibitor MK-0752 and Chemotherapeutic Agents Decreases Cellular Invasion and Increases Apoptosis. [Abstract]

2024 Jun 10;16(12):2184. PMID: 38927890
Front Biosci (Landmark Ed)

Macrophage Notch1 Participates in LPS-Induced Acute Lung Injury via Regulating CCR5 Expression in Mice. [Abstract]

2025 Apr 23;30(4):37430. PMID: 40302346
J Biol Chem

Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells. [Abstract]

2019 Jul 19;294(29):11276-11285. PMID: 31167792
J Cell Physiol

Vitamin C alleviates the senescence of periodontal ligament stem cells through inhibition of Notch3 during long-term culture. [Abstract]

2021 Feb;236(2):1237-1251. PMID: 32662081
J Cell Sci

Proprotein convertase furina is required for heart development in zebrafish. [Abstract]

2021 Oct 8;jcs.258432. PMID: 34622921
Mol Biol Rep

17β-estradiol inhibits Notch1 activation in murine macrophage cell line RAW 264.7. [Abstract]

2024 Nov 8;51(1):1134. PMID: 39514048
Reprod Fertil Dev

Notch signalling regulates steroidogenesis in mouse ovarian granulosa cells. [Abstract]

2019 May;31(6):1091-1103. PMID: 30827331
J Recept Signal Transduct Res

Function and mechanism exploration of zinc finger protein 64 in lung adenocarcinoma cell growth and metastasis. [Abstract]

2021 Oct;41(5):457-465. PMID: 33054540
Andrologia

Notch signaling inhibition induces G0/G1 arrest in murine Leydig cells. [Abstract]

2019 Nov;51(10):e13413. PMID: 31523838

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: Andrologia. 2019 Nov;51(10):e13413. [Abstract]

MK-0752 regulated the expression of cell proliferation-related genes at the mRNA and protein levels. The relative protein expression of p27 and p21Waf1/Cip1 in TM3 Leydig cells after treatment with 25 μM MK-0752 respectively. The representative Western blots for p27 and p21Waf1/Cip1 after treatment with MK-0752.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cook JJ, et al. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci. 2010;30(19):6743-6750. [Content Brief]

[2]. Krop I, et al. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J Clin Oncol. 2012;30(19):2307-2313. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MK-0752 sodium

14 Cited Publications

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Biologische Aktivität
- Beschreibung
Chemical Information
Publications (14)
Reinheit & Dokumentation
Verweise

1/16
1/16

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: Andrologia. 2019 Nov;51(10):e13413. [Abstract]

Customer Validation
MK-0752 regulated the expression of cell proliferation-related genes at the mRNA and protein levels. The relative protein expression of p27 and p21Waf1/Cip1 in TM3 Leydig cells after treatment with 25 μM MK-0752 respectively. The representative Western blots for p27 and p21Waf1/Cip1 after treatment with MK-0752.
1/16

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966. [Abstract]

Customer Validation
IC₅₀ curves of MK-0752 (10^-4-10⁴ nM) on cNOTCHsub.
1/16

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966. [Abstract]

Customer Validation
Dose responses of cAPPC100sub and full-length APP cleavage to MK-0752 (10^-4-10⁴ nM).
1/16

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966. [Abstract]

Customer Validation
MK-0752 (100 nM-12.5 μM) strongly decreased NICD levels in the breast cancer line MDA-MB-231.
1/16

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966. [Abstract]

Customer Validation
MK-0752 (0.5-12.5 μM) inhibited APP-CTF process in MDA-MB-231 cells in a dose-dependent manner.
1/16

MK-0752 sodium purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966. [Abstract]

Customer Validation
Absolute viable cell counts of mammospheres from MDA-MB-231 and MDA-MB-468 cell lines treated with MK-0752 (10 μM; 7 d).

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MK-0752 sodium

Publications Citing Use of MedChemExpress (MCE) MK-0752 sodium

Biologische Aktivität

Chemical Information

Publications (14)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MK-0752 sodium Related Classifications

HY-10975 Related Classifications