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Art. -Nr.: HY-163406

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PDE1-IN-6

PDE1-IN-6 (compound 6c) is a selectivity PDE1 inhibitor with the IC₅₀ of 7.5 nM. PDE1-IN-6 significantly inhibits the proliferation and induced cell apoptosis in Acute myelogenous leukemia cells.

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CAS. Nr.: 2877017-16-6
Formel: C₂₄H₂₆F₂N₆O
Molecular Weight:452.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PDE1-IN-6 Chemical Structure

CAS. Nr.: 2877017-16-6

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

PDE1-IN-6 (compound 6c) (10 and 20 μM, 48 h) induces the apoptosis of U937 and ML-1 cells^[1].
PDE1-IN-6 (10 and 20 μM, 48 h) decreases the expression of caspase-3, 7, 9, PARP, Bcl-2 and Bcl-xl protein, and increases their cleaved caspase-3, 7, 9 in U937 and ML-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

U937 and ML-1 cells
Concentration:

10, 20 μM
Incubation Time:

48 h
Result:

Induced the apoptosis of U937 and ML-1 cells.

Western Blot Analysis^[1]

Cell Line:

U937 and ML-1 cells
Concentration:

10, 20 μM
Incubation Time:

48 h
Result:

Decreased the expression of caspase-3, 7, 9, PARP, Bcl-2 and Bcl-xl protein, and increased their cleaved caspase-3, 7, 9.

Chemical Information

CAS. Nr. 2877017-16-6
Molecular Weight 452.50
Formel C₂₄H₂₆F₂N₆O
SMILES

CC(C)(N1N=CC2=C1N=C(N(C2=O)CC3=CC=CC(F)=C3)NCCNC4=CC=C(C=C4)F)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Le ML, et al. Discovery of novel selective phosphodiesterase‑1 inhibitors for the treatment of acute myelogenous leukemia. Bioorg Chem. 2024;144:107114. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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