Peginterferon beta-1a
Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS).
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- CAS. Nr.: 1211327-92-2
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Peginterferon beta-1a (0.001-1000 ng/mL; 5 d) affects cell viability of SK-MEL-2, SK-MEL-5, MeWo and WM-266-4 tumor cells[1]. Peginterferon beta-1a (10, 100, and 1,000 ng/mL) induces cell apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SK-MEL-1, SK-MEL-2, SK-MEL-5, MeWo and WM-266-4 tumor cell lines
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Concentration:0.001-1000 ng/mL
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Incubation Time:5 d
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Result:Inhibited the cell viability of SK-MEL-2, SK-MEL-5, MeWo and WM-266-4 tumor cells and showed an IC50 value of 2-3 ng/mL to WM-266-4 cells.
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Cell Line:WM-266-4 cell line
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Concentration:10, 100 and 1000 ng/mL
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Incubation Time:24 h
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Result:Induced the cleavage of PARP, caspase-8, and -9, induction of TRAIL and phosphorylation of STAT1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice with human SK-MEL-1 and A-375 melanoma xenografts[1]
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Dosage:0.1-1.6 mg/kg
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Administration:Subcutaneous injection; once/twice a week; for 3/4 weeks
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Result:Significantly inhibited SK-MEL-1 tumor growth at 0.4 mg/kg (QW; 3 w) and inhibited A-375 melanoma tumors at 1.6 mg/kg (BIW; 4 w).
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Animal Model:Nude mice with human WM-266-4 melanoma xenografts[1]
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Dosage:0.4-1.6 mg/kg
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Administration:Subcutaneous injection; 0.4-1.6 mg/kg; once/twice/three times a week for 4 w
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Result:The QW dose of 1.6 mg/kg and all doses given BIW and TIW induced tumor regression, with a 1.6 mg/kg QW dose induced significant tumor inhibition relative to 0.8 mg/kg QW.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1211327-92-2
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SMILES
[Peginterferon beta-1a]
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Synonyms
Peginterferon β-1a
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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