Pomalidomide-C6-COOH
Based on 1 Customer Validation
Pomalidomide-C6-COOH is the pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC.
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- Reinheit: 98.02%
- CAS. Nr.: 2225940-50-9
- Formel: C20H23N3O6
- Molecular Weight:401.41
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Alle E3 Ligase Ligand-Linker Conjugates Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2225940-50-9
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Appearance Solid
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Molecular Weight 401.41
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Formel C20H23N3O6
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Color Light yellow to yellow
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SMILES
O=C(O)CCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (311.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4912 mL | 12.4561 mL | 24.9122 mL | 62.2805 mL |
| 5 mM | 0.4982 mL | 2.4912 mL | 4.9824 mL | 12.4561 mL | |
| 10 mM | 0.2491 mL | 1.2456 mL | 2.4912 mL | 6.2280 mL | |
| 15 mM | 0.1661 mL | 0.8304 mL | 1.6608 mL | 4.1520 mL | |
| 20 mM | 0.1246 mL | 0.6228 mL | 1.2456 mL | 3.1140 mL | |
| 25 mM | 0.0996 mL | 0.4982 mL | 0.9965 mL | 2.4912 mL | |
| 30 mM | 0.0830 mL | 0.4152 mL | 0.8304 mL | 2.0760 mL | |
| 40 mM | 0.0623 mL | 0.3114 mL | 0.6228 mL | 1.5570 mL | |
| 50 mM | 0.0498 mL | 0.2491 mL | 0.4982 mL | 1.2456 mL | |
| 60 mM | 0.0415 mL | 0.2076 mL | 0.4152 mL | 1.0380 mL | |
| 80 mM | 0.0311 mL | 0.1557 mL | 0.3114 mL | 0.7785 mL | |
| 100 mM | 0.0249 mL | 0.1246 mL | 0.2491 mL | 0.6228 mL |
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