59 Results for "

GATA

" in MedChemExpress (MCE) Product Catalog:
Products (59)

59 Results for "GATA" in MCE Product Catalog:

15
K-7174
K-7174
0 Images
15 Publications Verification
Art. -Nr.: HY-12743
CAS. Nr.: 191089-59-5
Reinheit:  98.02%
Target:  

Proteasome Apoptosis

Forschungsgebiete:  

Inflammation/Immunology Cancer

K-7174 is an orally active proteasome and GATA inhibitor. K-7174 is a cell adhesion inhibitor. K-7174 induces cell apoptosis. K-7174 shows antitumor activities, it can be used for the research of cancer .
15
K-7174 dihydrochloride
K-7174 dihydrochloride
0 Images
15 Publications Verification
Art. -Nr.: HY-12743A
CAS. Nr.: 191089-60-8
Reinheit:  98.72%
Target:  

Proteasome Apoptosis

Forschungsgebiete:  

Inflammation/Immunology Cancer

K-7174 dihydrochloride is an orally active proteasome and GATA inhibitor. K-7174 dihydrochloride is a cell adhesion inhibitor. K-7174 dihydrochloride induces cell apoptosis. K-7174 dihydrochloride shows antitumor activities, it can be used for the research of cancer .
3
Caerulomycin A
Caerulomycin A
0 Images
3 Cited Publications
Art. -Nr.: HY-114495
CAS. Nr.: 21802-37-9
Reinheit:  ≥98.0%
Synonyms: Cerulomycin; Caerulomycin
Category:  

Microorganisms Anti-inflammation/Immunoregulatory Antibiotics Disease Research Antibacterial Anticancer Disease Research Fields Inflammation/Immunology Other Antibiotics

Target:  

Fungal Antibiotic

Caerulomycin A is an orally active immunomodulator and antimicrobial agent. Caerulomycin A targets Smad3, STAT1 and GATA-3. Caerulomycin A downregulates GATA-3 expression, inhibits Th2 cell differentiation and Th2 cytokine production, reduces IgE levels, and alleviates pulmonary inflammatory responses and eosinophil infiltration. Caerulomycin A ameliorates collagen-induced arthritis symptoms, reduces joint inflammation and synovitis, and decreases the levels of proinflammatory cytokines in joints. Caerulomycin A inhibits the growth of some filamentous fungi, yeasts and specific bacteria. Caerulomycin A can be used in research related to arthritis and asthma .
3
Platycodin D2
Platycodin D2
0 Images
3 Cited Publications
Art. -Nr.: HY-N4087
CAS. Nr.: 66663-90-9
Category:  

Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer

Target:  

Mitophagy Autophagy Ferroptosis Interleukin Related IFNAR Reactive Oxygen Species (ROS)

Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology .
1
Pyrrothiogatain
Pyrrothiogatain
0 Images
1 Cited Publications
Art. -Nr.: HY-138113
CAS. Nr.: 477888-48-5
Reinheit:  98.61%
Target:  

DNA/RNA Synthesis Interleukin Related TNF Receptor Angiotensin-converting Enzyme (ACE) SARS-CoV

Forschungsgebiete:  

Infection Inflammation/Immunology Cancer

Pyrrothiogatain is a transcription factor GATA3 inhibitor with an IC50 of 54.7 μM. Pyrrothiogatain inhibits the DNA-binding activity of GATA3 and inhibits the T helper 2 (Th2) cell differentiation and expression of Th2 cytokines. Pyrrothiogatain shows anti-infection effect by inhibiting ACE2 expression. Pyrrothiogatain can be used for the researches of inflammation, immunology, infection and cancer, such as colon cancer and SARS-CoV-2 infection .
ZAK-IN-1
ZAK-IN-1
0 Images
Art. -Nr.: HY-128326
CAS. Nr.: 2362525-64-0
Target:  

MAP3K

Forschungsgebiete:  

Cardiovascular Disease

ZAK-IN-1 is an orally active and selective selective leucine-zipper and sterile‑α motif kinase (ZAK) inhibitor with IC50 of 4 nM and KD of 8 nM. ZAK-IN-1 exhibits excellent selectivity against a panel of 403 wild-type kinases. ZAK-IN-1 blocks p38/GATA-4 and JNK/c-Jun signaling and shows promising anti antihypertrophic cardiomyopathy (HCM) efficacy. ZAK-IN-1 can be used for the study of HCM .
Picroside I
Picroside I
0 Images
Art. -Nr.: HY-N0407
CAS. Nr.: 27409-30-9
Synonyms: 6'-Cinnamoylcatalpol
Category:  

Iridoids Terpenoids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields Inflammation/Immunology

Target:  

STAT

Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .
Ginsenoside F3
Ginsenoside F3
0 Images
Art. -Nr.: HY-N0600
CAS. Nr.: 62025-50-7
Category:  

Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae

Target:  

Interleukin Related IFNAR NF-κB

Ginsenoside F3 is a saponin extracted from the leaves of Panax ginseng with immunoenhancing and antitumor immunostimulatory activities. Ginsenoside F3 upregulates RIPOR2 with a Kd value of 3.77 μM. Ginsenoside F3 enhances NF‑κB activation, upregulates T‑bet and downregulates GATA‑3, increases the production of IL‑2 and IFN‑γ, decreases the production of IL‑4 and IL‑10, reverses CD8⁺ T‑cell exhaustion, restores cytokine secretion, and enhances antitumor immunity in a mouse non‑small cell lung cancer model. Ginsenoside F3 can be used for the research of non-small cell lung cancer .
GATA1 Human Pre-designed siRNA Set A
GATA1 Human Pre-designed siRNA Set A
Art. -Nr.: HY-RS05289
Target:  

Small Interfering RNA (siRNA)

Forschungsgebiete:  

Others

GATA1 Human Pre-designed siRNA Set A contains three designed siRNAs for GATA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GATA2 Human Pre-designed siRNA Set A
GATA2 Human Pre-designed siRNA Set A
Art. -Nr.: HY-RS05290
Target:  

Small Interfering RNA (siRNA)

Forschungsgebiete:  

Others

GATA2 Human Pre-designed siRNA Set A contains three designed siRNAs for GATA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GATA3 Human Pre-designed siRNA Set A
GATA3 Human Pre-designed siRNA Set A
Art. -Nr.: HY-RS05291
Target:  

Small Interfering RNA (siRNA)

Forschungsgebiete:  

Others

GATA3 Human Pre-designed siRNA Set A contains three designed siRNAs for GATA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GATA6 Human Pre-designed siRNA Set A
GATA6 Human Pre-designed siRNA Set A
Art. -Nr.: HY-RS05294
Target:  

Small Interfering RNA (siRNA)

Forschungsgebiete:  

Others

GATA6 Human Pre-designed siRNA Set A contains three designed siRNAs for GATA6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Monarsen
Monarsen
0 Images
Art. -Nr.: HY-148412
CAS. Nr.: 864021-55-6
Synonyms: EN101; ODN 7040; BL 7040
Target:  

Cholinesterase (ChE)

Forschungsgebiete:  

Others

Monarsen (EN101) is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).
BSJ-05-037
BSJ-05-037
0 Images
Art. -Nr.: HY-185206
CAS. Nr.: 2756388-01-7
Target:  

PROTACs Itk NF-κB

Forschungsgebiete:  

Cancer

BSJ-05-037 is an ITK PROTAC degrader that effectively targets and degrades ITK in T-cell lymphoma cell lines. BSJ-05-037 blocks the activation of the NF-κB/GATA-3 signaling pathway, inhibits PLCγ1 phosphorylation, and reduces the proliferative capacity of T-cell lymphoma cells. BSJ-05-037 enhances the sensitivity of T-cell lymphoma cells to chemotherapy. In mouse models of T-cell lymphoma, BSJ-05-037 induces ITK degradation, reduces GATA-3 expression, decreases tumor volume, and reverses chemotherapy resistance. BSJ-05-037 is applicable to research related to T-cell lymphoma .
Ac-Tyr-Val-Lys-Asp-aldehyde
Ac-Tyr-Val-Lys-Asp-aldehyde
0 Images
Art. -Nr.: HY-P3761
CAS. Nr.: 147821-01-0
Target:  

Caspase

Forschungsgebiete:  

Inflammation/Immunology

Ac-Tyr-Val-Lys-Asp-aldehyde is a reversible caspase-1 inhibitor. Ac-Tyr-Val-Lys-Asp-aldehyde increases GATA1 levels by inhibiting caspase-1 and promotes erythroid differentiation. can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia .
Picroside I (Standard)
Picroside I (Standard)
0 Images
Art. -Nr.: HY-N0407R
CAS. Nr.: 27409-30-9
Synonyms: 6'-Cinnamoylcatalpol (Standard)
Category:  

Iridoids Terpenoids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell

Target:  

Reference Standards STAT

Picroside I (Standard) is the analytical standard of Picroside I. This product is intended for research and analytical applications. Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .
Human GATA3 mRNA
Human GATA3 mRNA
0 Images
Art. -Nr.: HY-174675
Target:  

mRNA

Forschungsgebiete:  

Cancer

Human GATA3 mRNA encodes the human GATA binding protein 3 (GATA3) which belongs to the GATA family. GATA3 is an important regulator of T-cell development. It also plays an important role in endothelial cell biology.
Human GATA4 mRNA
Human GATA4 mRNA
0 Images
Art. -Nr.: HY-174673
Target:  

mRNA

Forschungsgebiete:  

Cancer

Human GATA4 mRNA encodes the human GATA binding protein 4 (GATA4) protein, a member of the GATA family of zinc-finger transcription factors. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. It is also necessary for normal testicular development.
Human GATA2 mRNA
Human GATA2 mRNA
0 Images
Art. -Nr.: HY-174676
Target:  

mRNA

Forschungsgebiete:  

Cancer

Human GATA2 mRNA encodes the human GATA binding protein 2 (GATA2) protein, a member of the GATA family of zinc-finger transcription factors. GATA2 plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages.
Mouse Gata4 mRNA
Mouse Gata4 mRNA
0 Images
Art. -Nr.: HY-174481
Target:  

mRNA

Forschungsgebiete:  

Cardiovascular Disease

Mouse Gata4 mRNA encodes the mouse GATA binding protein 4 (Gata4) protein, a transcriptional activator that binds to the consensus sequence 5''-AGATAG-3'' and plays a key role in cardiac development.
Assay Types