27409-30-9
Chemical Structure
Picroside I
Synonym(s): 6'-Cinnamoylcatalpol
- CAS No.: 27409-30-9
- Formula:C24H28O11
- Molecular Weight:492.47
IUPAC Name: ((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((1aS,1bS,2S,5aR,6S,6aS)-6-hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl cinnamate
InChIKey: XZGPUOQGERGURE-LUVHZPKESA-N
SMILES: OC[C@]12[C@@H](O2)[C@@H](O)[C@@]3([H])[C@]1([H])[C@H](O[C@]4([H])O[C@H](COC(/C=C/C5=CC=CC=C5)=O)[C@@H](O)[C@H](O)[C@H]4O)OC=C3
Biological Activity: Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II[1]. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ[2].
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Picroside I | 99.31% | Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ. | ||||||||||||||||||||
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Picroside I (Standard) | ≥98% | Picroside I (Standard) is the analytical standard of Picroside I. This product is intended for research and analytical applications. Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ. | ||||||||||||||||||||
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References
- [1]. Ganeshkumar Y, et al. Picroside I and Picroside II from Tissue Cultures of Picrorhiza kurroa. Pharmacognosy Res. 2017 Dec;9(Suppl 1):S53-S56. [Content Brief]
- [2]. Sen Zhang, et al. Picroside I inhibits asthma phenotypes by regulating Tbet/GATA-3 ratio and Th1/Th2 balance in a murine model of asthma. Tropical Journal of Pharmaceutical Research September 2018; 17 (9): 1777-1782.
