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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
hyperproliferative
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "hyperproliferative" in MCE Product Catalog:
3
Target:
Forschungsgebiete:
Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation .
1
1 Cited Publications
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Forschungsgebiete:
M1069 is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity .
Target:
Forschungsgebiete:
KDM2B-IN-4 (Compound 182b) is a histone demethylase KDM2B inhibitor with an IC50 of 1.12 nM. KDM2B-IN-4 can be used for the research of hyperproliferative diseases such as cancers .
Target:
Forschungsgebiete:
KDM2B-IN-1 (Example 20) is an effective inhibitor of histone demethylase (KDM2B), with an IC50 value of 0.021 μM. KDM2B-IN-1 can be used in proliferative diseases, such as cancer research .
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Forschungsgebiete:
KDM2B-IN-1 (example 32) is a histone demethylase (kdm2b) inhibitor with an IC50 of 0.016 nM. KDM2B-IN-1 can be used for hyperproliferative diseases research .
Art. -Nr.: HY-16461
CAS. Nr.: 137038-57-4
Synonyms: (-)-Solenopsin A
Target:
Akt Ribosomal S6 Kinase (RSK) PI3K PDK-1 FOXO Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism
Forschungsgebiete:
Solenopsin ((-)-Solenopsin A) is an ATP-competitive and selective Akt-1 inhibitor with an IC50 of 5-10 μM, and also acts as an RSK1 inhibitor. Solenopsin inhibits the activities of PDK1 in lipid rafts, downregulates PI3K, blocks PI3K-dependent generation of 3-phosphoinositides, and suppresses the phosphorylation of FOXO1a. Solenopsin induces Mitophagy and ROS production, reduces mitochondrial oxygen consumption, and exhibits antiproliferative and antiangiogenic activities. Solenopsin can be used in research related to hyperproliferative skin diseases and malignant diseases .
Art. -Nr.: HY-163499
CAS. Nr.: 3034103-84-6
Target:
Forschungsgebiete:
NAMPT activator-7 is a NAMPT activator with an EC50 of <0.5 μM. NAMPT activator-7 can be used in research related to heart disease, Alzheimer's disease, Huntington's disease, Parkinson's disease and spinal cord injury .
Art. -Nr.: HY-163500
CAS. Nr.: 3034104-30-5
Target:
Forschungsgebiete:
NAMPT activator-7 is a NAMPT activator with an EC50 of <0.5 μM. NAMPT activator-7 can be used in research related to heart disease, Alzheimer's disease, Huntington's disease, Parkinson's disease and spinal cord injury .
Art. -Nr.: HY-W000773
CAS. Nr.: 937046-98-5
Target:
Forschungsgebiete:
7-Bromopyrrolotriazin-4-amine (Compound 3-7) is a pyrrolotriazine derivative. 7-Bromopyrrolotriazin-4-amine is applicable to the study of hyperproliferative diseases and angiogenesis-related diseases .
Art. -Nr.: HY-142677
CAS. Nr.: 2742654-38-0
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Forschungsgebiete:
PI3K-IN-27 is a potent inhibitor of PI3K. PI3K belongs to a large family of lipid signaling kinase that plays key role in cellular process including cell growth, differentiation, migration and apoptosis. PI3K-IN-27 has the potential for the research of hyper-proliferative diseases like cancer and inflammation, or immune and autoimmune diseases (extracted from patent WO2021233227A1, compound 1) .
Art. -Nr.: HY-121638B
CAS. Nr.: 861123-84-4
Target:
Forschungsgebiete:
Infection Cardiovascular Disease Inflammation/Immunology Cancer
(E/Z)-CU-3 is a MCL-1 modulator. (E/Z)-CU-3 can be used to study hyperproliferative diseases, angiogenic diseases, cell cycle regulation diseases, autophagy regulation diseases, inflammatory diseases and/or infectious diseases .
Art. -Nr.: HY-175734
CAS. Nr.: 2019131-11-2
Target:
Forschungsgebiete:
PI3Kδ-IN-26 (Compound 58) is a selective and orally active PI3Kδ inhibitor with an IC50 of 14 nM. PI3Kδ-IN-26 significantly attenuates the inflammatory responses in house dust mite (HDM) induced chronic asthma mouse models. PI3Kδ-IN-26 can be used for inflammatory, autoimmune and hyperproliferative diseases research .
Art. -Nr.: HY-U00366
CAS. Nr.: 1149727-61-6
Target:
Forschungsgebiete:
S1PR-MO-1 is the modulator of sphingosine-1-phosphate receptor, used for research of hyperproliferative, inflammatory diseases.
Forschungsgebiete:
TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis .
Synonyms: Trisoralen (Standard); Trioxysalen (Standard); TMP (Standard)
Forschungsgebiete:
Trioxsalen (Standard) is the analytical standard of Trioxsalen. This product is intended for research and analytical applications. Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation .
Art. -Nr.: HY-155243
CAS. Nr.: 857758-13-5
Target:
Forschungsgebiete:
12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research .
Art. -Nr.: HY-155865
CAS. Nr.: 2902671-74-1
CCT368772 (compound 35) is a selective kinesin HSET inhibitor (HSET ADP-Glo IC50 = 0.019 μM). CCT368772 exhibits selectivity over Eg5 (Eg5 ADP-Glo IC50 >200 μM) . CCT368772 (compound 152) can be used for the study of hyperproliferative diseases and disorders such as cancer .
Art. -Nr.: HY-164534
CAS. Nr.: 1648864-21-4
Target:
Forschungsgebiete:
SIK2/3-IN-2 (compound 12, compound I-200) is a potent SIK2/3 inhibitor (SIK2 IC50 = 65 nM, SIK3 IC50 = 14 nM). SIK2/3-IN-2 is also a p21-activated protein kinase (PAK) 1 inhibitor with a Ki of 20.7 nM. SIK2/3-IN-2 can be used for hyperproliferative diseases and cancer research, such as Paclitaxel (HY-B0015)-resistant ovarian cancer .
Art. -Nr.: HY-177274
CAS. Nr.: 182878-97-3
Target:
Forschungsgebiete:
Antimitotic agent-2 (Compound 1) is an antimitotic agent. Antimitotic agent-2 inhibits the proliferation of human epidermal cells. Antimitotic agent-2 can be used in hyperproliferative skin disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
