Tacalcitol monohydrate
Based on 3 publication(s) in Google Scholar
Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3 monohydrate) can promote normal bone growth by regulating calcium ions. Tacalcitol monohydrate inhibits cancer cell proliferation and migration. Tacalcitol monohydrate can be used in the research of inflammation, cancer, and skin diseases.
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- Reinheit: 99.85%
- CAS. Nr.: 93129-94-3
- Formel: C27H46O4
- Molecular Weight:434.65
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Speicherung:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Tacalcitol monohydrate
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Biologische Aktivität
Tacalcitol (0.1-100 μM, 24 h) monohydrate inhibits synthesis of both IL-6 and IL-8 in cultures derived from nasal polyps in dose-dependent manner[1].
Tacalcitol (10-4-1 μM, 48 h or one week) monohydrate induces cell differentiation in normal human keratinocytes. Tacalcitol inhibits the growth of normal and psoriatic human keratinocytes[2][3].
Tacalcitol (0-1 μM, 48 h) monohydrate inhibits DNA synthesis in normal human keratinocytes[3].
Tacalcitol (0.001-10 μM, 6 days) monohydrate strongly reduces proliferation of human glioblastoma[4].
Tacalcitol (10 μM, 41 h) monohydrate inhibits human glioblastoma migration[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:normal human keratinocytes
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Concentration:10-10, 10-9, 10-8, 10-7, 10-6 M
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Incubation Time:one week
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Result:Significantly inhibited the growth of human keratinocytes at concentrations higher than 10-8 M.
The growth of keratinocytes was 65% inhibited by 10-8 M and 90% inhibited by 10-7 M
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Cell Line:T98G cells
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Concentration:0.001, 0.01, 0.1, 1, 10 μM
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Incubation Time:6 days
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Result:Treatment for 6 days resulted in a significant, dose-dependent inhibitory effect on cell viability/growth.
Treatment of cells for less than 6 days did not influence cell viability/growth.
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Cell Line:T98G cells
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Concentration:10 μM
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Incubation Time:41 h (pre-treated for 24 h, then cells were scraped and monitore for 17 h)
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Result:Reduced the migration rate.
After 17 hr, the wound closure of control cells was about 60%, while treated cells had a wound closure of about 35-45%.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female SKH1 (hr/hr) hairless mice (7-8 weeks old, Phorbol 12-myristate 13-acetate (HY-18739) (12-Otetradecanoylphorbol 13-acetate (TPA)) was topically applied to 6 cm2 area of the dorsal skin to induce cutaneous inflammation)[5]
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Dosage:0.2, 2, 20 μg/g
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Administration:Applied to the cutaneous inflammation area
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Result:Significantly inhibited TPA-induced cutaneous inflammation, histopathologically.
The effect of 20 μg/g on cutaneous inflammation was much stronger than that of 2 μg/g.
20 μg/g also significantly inhibited TPA-induced myeloperoxidase (MPO) activity.
The effect on epidermal proliferation was significant at the doses of 2 μg/g and 20 μg/g, and that on epidermal differentiation was significant at the doses of 0.2 μg/g or more.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 93129-94-3
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Appearance Solid
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Molecular Weight 434.65
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Formel C27H46O4
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Color White to off-white
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SMILES
CC([C@@H](CC[C@H]([C@@H](CC[C@]1/2[H])[C@@]1(C)CCCC2=C/C=C3C[C@@H](C[C@H](C/3=C)O)O)C)O)C.[H]O[H]
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Synonyms
1,24(R)-Dihydroxyvitamin D3 monohydrate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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Virol Sin
Antiviral activity of vitamin D derivatives against severe fever with thrombocytopenia syndrome virus in vitro and in vivo. [Abstract]2024 Aug 19:S1995-820X(24)00134-2. PMID: 39168248 -
FEBS Open Bio
Vitamin D3 suppresses the cholesterol homeostasis pathway in patient-derived glioma cell lines. [Abstract]2023 Sep;13(9):1789-1806. PMID: 37489660 -
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Rostkowska-Nadolska B, et al. Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures. Adv Med Sci. 2010;55(1):86-92. [Content Brief]
[2]. Kobayashi T, et al. 1 alpha,24R-dihydroxyvitamin D3 has an ability comparable to that of 1 alpha,25-dihydroxyvitamin D3 to induce keratinocyte differentiation. J Dermatol. 1990 Nov;17(11):707-9. [Content Brief]
[3]. Matsumoto K, et al. K. Effect of 1,24R-dihydroxyvitamin D3 on the growth of human keratinocytes. J Dermatol. 1990 Feb;17(2):97-103. [Content Brief]
[4]. Emanuelsson I, et al. Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells. Basic Clin Pharmacol Toxicol. 2018 Aug;123(2):130-136. [Content Brief]
[5]. Sato H, et al. Pharmacological profiles of high-concentration (20 microg/g) tacalcitol ointment: effects on cutaneous inflammation, epidermal proliferation, and differentiation in mice. J Dermatol. 2003 Jul;30(7):510-24. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Tacalcitol monohydrate Related Classifications
HY-32338 Related Classifications
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