H6pd - hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) Gene

Also Known as H6pdh

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 298655

Summary

Enables NADP binding activity; carbohydrate binding activity; and glucose-6-phosphate dehydrogenase activity. Involved in NADP metabolic process; carbohydrate metabolic process; and response to alcohol. Located in mitochondrion. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 1; and multiple sclerosis. Orthologous to human H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

H6pd Products (1)

mRNA Protein Name
NM_001106698.1 NP_001100168.1 GDH/6PGL endoplasmic bifunctional protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NADP binding IDA
IDA: Inferred from direct assay
6813321 RGD
enables carbohydrate binding IDA
IDA: Inferred from direct assay
6813321 RGD
enables glucose-6-phosphate dehydrogenase activity IDA
IDA: Inferred from direct assay
6813321 RGD
Biological Process GO Annotation Evidence References Source
involved in NADP metabolic process IDA
IDA: Inferred from direct assay
6813321 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
17122334 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25943649 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GDH/6PGL endoplasmic bifunctional protein

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10617A Rucaparib Inhibitor 99.96% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.91% Yes
HY-102003A Rucaparib camsylate Inhibitor / Unkown
HY-10617C Rucaparib tartrate Inhibitor / Unkown
HY-10617B Rucaparib hydrochloride Inhibitor / Unkown
HY-10617D Rucaparib acetate Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10617AS1 Rucaparib-d3 Inhibitor / Unkown
HY-RS05980 H6PD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10617AS Rucaparib-d8 Inhibitor / Unkown
HY-RS17126 H6pd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23571 H6pd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens H6pd NCBI NCBI:9563