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Cat. No.: HY-10617AS1

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Rucaparib-d₃

(Synonyms: AG014699-d₃; PF-01367338-d₃)

Rucaparib-d₃ (AG014699-d₃) is the deuterated -labeled Rucaparib (HY-10617A). Rucaparib (AG014699) is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a K_i of 1.4 nM for PARP1. Rucaparib is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib has the potential for castration-resistant prostate cancer (CRPC) research.

For research use only. We do not sell to patients.

CAS No.: 2271225-13-7
Formula: C₁₉H₁₅D₃FN₃O
Molecular Weight:326.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rucaparib-d₃ Chemical Structure

CAS No.: 2271225-13-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PARP Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Animal Model:

Female CD-1 nude mice aged 10-12 weeks with Capan-1 cells^[2]
Dosage:

10 mg/kg for i.p. or 50, 150 mg/kg for p.o.
Administration:

IP or PO
Result:

Significantly inhibited the growth of the tumor.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2271225-13-7
Unlabeled Cas 283173-50-2
Molecular Weight 326.38
Formula C₁₉H₁₅D₃FN₃O
SMILES

O=C1C2=C3C(CCN1)=C(C4=CC=C(C=C4)CNC([2H])([2H])[2H])NC3=CC(F)=C2
Synonyms

AG014699-d₃; PF-01367338-d₃
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.