4-Chloropyridine
4-Chloropyridine is a NNMT (Nicotinamide N-methyltransferase) substrate and suicide inhibition-based protein labeling scaffold precursor.4-Chloropyridine undergoes NNMT-catalyzed pyridine nitrogen methylation to increase C4 electrophilicity, enabling aromatic nucleophilic substitution by NNMT cysteine C159 for covalent NNMT modification and inactivation.4-Chloropyridine can be used for the research of various cancers.
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- CAS No.: 626-61-9
- Formule: C5H4ClN
- Masse moléculaire:113.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
4-chloropyridine acts as a substrate for wild-type human NNMT with a KM of 44 μM[1].
4-chloropyridine (0.5 mM; 0.5 h) functions as a suicide inhibitor of wild-type human NNMT, causing time-dependent inactivation with a kobs/[I] of 20 M−1 min−1 and covalently modifying the enzyme[1].
4-chloropyridine (2 h) inhibits NNMT activity in NNMT-overexpressing HEK293T cells with an EC50 value of 87 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 626-61-9
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Masse moléculaire 113.54
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Formule C5H4ClN
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SMILES
ClC1=CC=NC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (268 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Chloropyridine Related Classifications
HY-W093017 Related Classifications
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