626-61-9
Chemical Structure
4-Chloropyridine
- CAS No.: 626-61-9
- Formula:C5H4ClN
- Molecular Weight:113.54
IUPAC Name: 4-chloropyridine
InChIKey: PVMNPAUTCMBOMO-UHFFFAOYSA-N
SMILES: ClC1=CC=NC=C1
Biological Activity: 4-Chloropyridine is a NNMT (Nicotinamide N-methyltransferase) substrate and suicide inhibition-based protein labeling scaffold precursor.4-Chloropyridine undergoes NNMT-catalyzed pyridine nitrogen methylation to increase C4 electrophilicity, enabling aromatic nucleophilic substitution by NNMT cysteine C159 for covalent NNMT modification and inactivation.4-Chloropyridine can be used for the research of various cancers[1].
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4-Chloropyridine | 4-Chloropyridine is a NNMT (Nicotinamide N-methyltransferase) substrate and suicide inhibition-based protein labeling scaffold precursor.4-Chloropyridine undergoes NNMT-catalyzed pyridine nitrogen methylation to increase C4 electrophilicity, enabling aromatic nucleophilic substitution by NNMT cysteine C159 for covalent NNMT modification and inactivation.4-Chloropyridine can be used for the research of various cancers. | |||||||||||||||||||||
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Keywords
