2. Metabolic Enzyme/Protease
  3. Amine N-methyltransferase
  4. 4-Chloropyridine

4-Chloropyridine is a NNMT (Nicotinamide N-methyltransferase) substrate and suicide inhibition-based protein labeling scaffold precursor.4-Chloropyridine undergoes NNMT-catalyzed pyridine nitrogen methylation to increase C4 electrophilicity, enabling aromatic nucleophilic substitution by NNMT cysteine C159 for covalent NNMT modification and inactivation.4-Chloropyridine can be used for the research of various cancers.

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4-Chloropyridine

4-Chloropyridine Chemical Structure

CAS No. : 626-61-9

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4-Chloropyridine Related Antibodies

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Description

4-Chloropyridine is a NNMT (Nicotinamide N-methyltransferase) substrate and suicide inhibition-based protein labeling scaffold precursor.4-Chloropyridine undergoes NNMT-catalyzed pyridine nitrogen methylation to increase C4 electrophilicity, enabling aromatic nucleophilic substitution by NNMT cysteine C159 for covalent NNMT modification and inactivation.4-Chloropyridine can be used for the research of various cancers[1].

In Vitro

4-chloropyridine acts as a substrate for wild-type human NNMT with a KM of 44 μM[1].
4-chloropyridine (0.5 mM; 0.5 h) functions as a suicide inhibitor of wild-type human NNMT, causing time-dependent inactivation with a kobs/[I] of 20 M−1 min−1 and covalently modifying the enzyme[1].
4-chloropyridine (2 h) inhibits NNMT activity in NNMT-overexpressing HEK293T cells with an EC50 value of 87 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4-Chloropyridine Related Antibodies
Molecular Weight

113.54

Formula

C5H4ClN
CAS No.
SMILES

ClC1=CC=NC=C1
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References
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4-Chloropyridine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Chloropyridine626-61-9Amine N-methyltransferasecovalent NNMT modificationC165A mutant NNMTNicotinamide N-methyltransferase (NNMT)cysteine C159HEK293T cellssuicide inhibitionNNMT-overexpressing cellsaromatic nucleophilic substitutionwild-type human NNMTC159A mutant NNMTInhibitorinhibitorinhibit

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