AF-353 hydrochloride
AF-353 hydrochloride is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3.
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- CAS No.: 927887-18-1
- Formule: C14H18ClIN4O2
- Masse moléculaire:436.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Chemical Information
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CAS No. 927887-18-1
-
Masse moléculaire 436.68
-
Formule C14H18ClIN4O2
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SMILES
IC1=C(OC)C=C(C(C)C)C(OC2=CN=C(N)N=C2N)=C1.Cl
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Synonyms
Ro-4 hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-1398. [Content Brief]
[2]. Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110(8 Pt B):E409-414. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AF-353 hydrochloride Related Classifications
HY-14483A Related Classifications
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