927887-18-1
927887-18-1
Chemical Structure
AF-353 hydrochloride
Synonym(s): Ro-4 hydrochloride
- CAS No.: 927887-18-1
- Formula:C14H18ClIN4O2
- Molecular Weight:436.68
InChIKey: QRBBKDZPXABQPE-UHFFFAOYSA-N
SMILES: IC1=C(OC)C=C(C(C)C)C(OC2=CN=C(N)N=C2N)=C1.Cl
Biological Activity: AF-353 hydrochloride is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2].
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AF-353 hydrochloride | AF-353 hydrochloride is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3. | |||||||||||||||||||||
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References
- [1]. Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-1398. [Content Brief]
- [2]. Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110(8 Pt B):E409-414. [Content Brief]
