Apoptosis inducer 8
Apoptosis inducer 8 (Compound 7c) is a galectin-1 (gal-1) mediated apoptosis-inducing agent against global major leading lung cancer burden. Apoptosis inducer 8 significantly reduced the gal-1 protein level. Apoptosis inducer 8 is also a PET imaging agent.
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- CAS No.: 2470024-51-0
- Formule: C29H22ClN5O2
- Masse moléculaire:507.97
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Galectin-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.63 μM
Compound: 74
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Anticancer activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 34146913] |
| MCF7 | IC50 |
1.3 μM
Compound: 74
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Anticancer activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 34146913] |
| NCI-H460 | IC50 |
0.99 μM
Compound: 74
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Anticancer activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Anticancer activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 34146913] |
Apoptosis inducer 8 (Compound 7c) exhibits an excellent growth inhibition against A-549, NCI-H460, MCF-7 and MDA-MB-23 cells with IC50 values of 0.63 ± 0.21, 0.99 ± 0.01, 1.3 ± 0.18 and 0.94 ± 0.02 µM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2470024-51-0
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Masse moléculaire 507.97
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Formule C29H22ClN5O2
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SMILES
OC1=CC=CC(N2N=NC(COC3=CC=C(C4=NC5=CC(Cl)=CC=C5N4CC6=CC=CC=C6)C=C3)=C2)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 8 Related Classifications
HY-147865 Related Classifications
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