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Cat. No.: HY-N9477

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Betulinic aldehyde oxime

(Synonyms: Betulin-28-oxime)

Betulinic aldehyde oxime (Compound 31) is a betulin (HY-N0083) derivative that has antimicrobial properties against E. aerogenes, E. coli, E. faecalis, P. aeruginosa, S. aureus, and C. albicans. Betulinic aldehyde oxime displays cytotoxicity towards hepatocytes, with an IC₅₀ of 25 μM.

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CAS No.: 25613-12-1

Formule: C₃₀H₄₉NO₂

Masse moléculaire:455.72

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Betulinic aldehyde oxime Chemical Structure

CAS No.: 25613-12-1

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Data Download

Data Sheet (268 KB)

Instruction de manipulation (2659 KB)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Activité biologique

Description

Betulinic aldehyde oxime (Compound 31) is a betulin (HY-N0083) derivative that has antimicrobial properties against E. aerogenes, E. coli, E. faecalis, P. aeruginosa, S. aureus, and C. albicans. Betulinic aldehyde oxime displays cytotoxicity towards hepatocytes, with an IC₅₀ of 25 μM^[1].

Cellular Effect

Cell Line

Type Value Description References

J774 IC₅₀
0.3 μM
Compound: 3

Antiinflammatory activity against mouse J774 cells assessed as inhibition of LPS-induced iNOS expression after 24 hrs by Western blot analysis

Antiinflammatory activity against mouse J774 cells assessed as inhibition of LPS-induced iNOS expression after 24 hrs by Western blot analysis
[PMID: 26915998]

J774.A1 IC₅₀
>10 μM
Compound: 17

Cytotoxicity against mouse J774.A1 cells

Cytotoxicity against mouse J774.A1 cells
[PMID: 25240731]

Chemical Information

CAS No. 25613-12-1

Masse moléculaire 455.72

Formule C₃₀H₄₉NO₂

SMILES

O/N=C/[C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC4)C)([H])CC3)C)C

Synonyms

Betulin-28-oxime

Structure Classification

Terpenoids

Triterpenes

Initial Source

Plants

Betulaceae

Betula platyphylla Sukaczev

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Haque S, et al. Screening and characterisation of antimicrobial properties of semisynthetic betulin derivatives. PLoS One. 2014 Jul 17;9(7):e102696. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Betulinic aldehyde oxime Related Classifications

HY-N9477 Related Classifications

Others Anti-infection

Drug Derivative Bacterial

Aires thérapeutique

Infection

Produits naturels

Plants Terpenoids

Betulaceae Triterpenes

Betula platyphylla Sukaczev

Infection

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Keywords

Betulinic aldehyde oxime
25613-12-1
Betulin-28-oxime
Drug Derivative
Bacterial
E. aerogenes
E. coli
E. faecalis
P. aeruginosa
S. aureus
C. albicans
hepatocytes
betulin
Inhibitor
inhibitor
inhibit

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Cell Line	Type	Value	Description	References
J774	IC₅₀	0.3 μM Compound: 3	Antiinflammatory activity against mouse J774 cells assessed as inhibition of LPS-induced iNOS expression after 24 hrs by Western blot analysis Antiinflammatory activity against mouse J774 cells assessed as inhibition of LPS-induced iNOS expression after 24 hrs by Western blot analysis	[PMID: 26915998]
J774.A1	IC₅₀	>10 μM Compound: 17	Cytotoxicity against mouse J774.A1 cells Cytotoxicity against mouse J774.A1 cells	[PMID: 25240731]

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