DHFR-IN-1
DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249.
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- CAS No.: 2757991-65-2
- Formule: C22H22N6O4S2
- Masse moléculaire:498.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 40.71 ± 1.86 nM (DHFR)[1]
Chemical Information
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CAS No. 2757991-65-2
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Masse moléculaire 498.58
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Formule C22H22N6O4S2
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SMILES
CN1CCN(CC1)S(=O)(C2=CC=C3NC(/C(C3=C2)=N\NC4=NC(C5=CC=C(C=C5)O)=CS4)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DHFR-IN-1 Related Classifications
HY-143236 Related Classifications
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