Fibrostatin C
Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery.
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- CAS No.: 91776-47-5
- Formule: C18H19NO8S
- Masse moléculaire:409.41
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Chemical Information
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CAS No. 91776-47-5
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Masse moléculaire 409.41
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Formule C18H19NO8S
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SMILES
O=C([C@@H](NC(C)=O)CSCC(C(O)=C1C2=O)=C(C=C1C(C(OC)=C2)=O)OC)O
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Synonyms
P-23924C
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Structure Classification
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Initial Source
Streptomyces
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Ishimaru T, et al. Inhibition of prolyl hydroxylase activity and collagen biosynthesis by fibrostatin C, a novel inhibitor produced by Streptomyces catenulae subsp. griseospora No. 23924. J Antibiot (Tokyo). 1988 Nov;41(11):1668-74. [Content Brief]
[2]. Saika S, et al. Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro. Graefes Arch Clin Exp Ophthalmol. 1996 Aug;234 Suppl 1:S214-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fibrostatin C Related Classifications
HY-129502 Related Classifications
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