Chl1 - cell adhesion molecule L1-like Gene

Also Known as CALL; LICAM2; A530023M13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12661

Summary

Enables protease binding activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including adult locomotory behavior; exploration behavior; and generation of neurons. Located in apical part of cell and dendrite. Is expressed in nervous system and retina. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CHL1 (cell adhesion molecule L1 like). [provided by Alliance of Genome Resources, Apr 2022]

Chl1 Products (1)

mRNA Protein Name
NM_007697.2 NP_031723.2 neural cell adhesion molecule L1-like protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protease binding IPI
IPI: Inferred from physical interaction
14761956 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18046458 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
14659567 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
12391163 MGI
acts upstream of or within cognition IMP
IMP: Inferred from mutant phenotype
14659567 MGI
acts upstream of or within exploration behavior IMP
IMP: Inferred from mutant phenotype
12391163 MGI
NOT acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
10103075 MGI
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
14761956 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
15504324 MGI
acts upstream of or within neuron projection development IDA
IDA: Inferred from direct assay
10103075 MGI
Cellular Component GO Annotation Evidence Références Source
located in apical part of cell IDA
IDA: Inferred from direct assay
15504324 MGI
located in dendrite IDA
IDA: Inferred from direct assay
15504324 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neural cell adhesion molecule L1-like protein

  • cell adhesion molecule with homology to L1CAM

  • chl1-like protein

  • close homolog of L1

Chl1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Chl1 P70232 Ptpra Mus musculus P18052
Anti Tag CoIP
18046458
Intra
Chl1 P70232 Cntn6 Mus musculus Q9JMB8
IF
18046458
Intra
Chl1 P70232 Cntn6 Mus musculus Q9JMB8
Anti Tag CoIP
18046458
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Chl1 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P75344 CHL1 Protein, Mouse (HEK293, His) XP_017176866 (A25-Q1027) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75345 CHL1 Protein, Mouse (HEK293, hFc) XP_017176866 (A25-Q1027) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75346 CHL1 Protein, Mouse (HEK293) XP_017176866 (A25-Q1027) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-153685 NISC-6 / Unkown
HY-RS02635 CHL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03631 DDX11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17802 Chl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18418 Chrdl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21547 Ddx11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24270 Chl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chl1 NCBI NCBI:10752