CHL1 Protein, Mouse (HEK293, hFc)
CHL1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived CHL1 protein, expressed by HEK293, with C-hFc labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
CHL1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived CHL1 protein, expressed by HEK293, with C-hFc labeled tag.
Background
CHL1 is an extracellular matrix and cell adhesion protein involved in nervous system development and synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth in cerebellar and hippocampal neurons while suppressing neuronal cell death. It contributes to pyramidal neuron positioning and regulates interneuron numbers and GABAergic synapse efficacy. CHL1 may also modulate cell migration during nerve regeneration and cortical development. Additionally, it enhances integrin-dependent cell migration toward extracellular matrix proteins. By similarity, it recruits ANK3 to the plasma membrane.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-hFc
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Accession
XP_017176866 (A25-Q1027)
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Molecular Construction
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N-term
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CHL1 (A25-Q1027)
Accession # XP_017176866 -
hFc
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C-term
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Protein Length
Partial
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Synonyms
CHL1; Cell Adhesion Molecule With Homology To L1CAM (Close Homolog Of L1); Cell Adhesion Molecule L1 Like; MGC132578; Close Homolog Of L1; FLJ44930; CALL; Cell Adhesion Molecule L1-Like; Neural Cell Adhesion Molecule L1-Like Protein; Neural Cell Adhesion
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AA Sequence
AEIPLSVQQVPTIVKQSYVQVAFPFDEYFQIECEAKGNPEPIFSWTKDDKPFDLSDPRIIAANNSGTFKIPNEGHISHFQGKYRCFASNRLGTAVSEEIEFIVPGVPKFPKEKIEPIDVEEGDSIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQRGDLYFANVEENDSRNDYCCFAAFPKLRTIVQKMPMKLTVNSSNSIKQRKPKLLLPPAQMGSLSAKTVLKGDTLLLECFAEGLPTPHIQWSKPGSELPEGRATIEVHEKTLKIENISYQDRGNYRCTANNLLGKASHDFHVTVEEPPRWKKKPQSAVYSTGSSGILLCEAEGEPQPTIKWRLNGLPIEKHPFPGDFMFPREISFTNLLPNHTGVYQCEASNIHGTILANANIDVIDVIPLIKTKNEENYATVVGYSAFLHCEYFASPKATVVWEVADETHPLEGDRYHTHENGTLEIYRTTEEDAGSYSCWVDNAMGKAVITANLDIRNATKLRVSPKNPRIPKSHVLELYCESQCDSHLKHSLKLSWSKDGEAFEMNGTEDGRIVIDGAYLTISNITAEDQGVYSCSAQTSLDSTSEKTQVTVLGVPDPPGNLHLSERQNRSVRLSWEAGDDHNSKISEYIVEFEGNREEPGKWEELTRVQGEETDVVLSLAPYVRYQFRVTAVNEVGRSHASLPSDHHETPPAAPDKNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYKVSWKPQGAPEEWEEEIVTNHTLRVMTPTVYAPYDVKVQAINQLGSSPDPQPVTLYSGEDYPSTAPVIQRVDVMNSTLVKVTWSSIPKETVHGLLRGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDPFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPSFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYELGELNEINVTTPSKSSWHLSNLNSTTKYKFYLRACTSRGCGKPISEEGATLGEGKYAGLYDDISTQ
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Predicted Molecular Mass
139.4 kDa
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Molecular Weight
Approximately 140 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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