FUT8 - fucosyltransferase 8 Gene

Also Known as CDGF; CDGF1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2530

About FUT8

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:65,356,842-65,744,121 (from NCBI)

This gene has 17 transcripts (splice variants), 267 orthologues and is associated with 2 phenotypes. Ubiquitous expression in stomach (RPKM 6.3), brain (RPKM 5.7) and 25 other tissues.

Summary

This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from Other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of Cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

FUT8 Products (6)

mRNA Protein Name
NM_001371533.1 NP_001358462.1 alpha-(1,6)-fucosyltransferase isoform a
NM_001371534.1 NP_001358463.1 alpha-(1,6)-fucosyltransferase isoform a
NM_001371536.1 NP_001358465.1 alpha-(1,6)-fucosyltransferase isoform c
NM_004480.4 NP_004471.4 alpha-(1,6)-fucosyltransferase isoform b
NM_178155.3 NP_835368.1 alpha-(1,6)-fucosyltransferase isoform a
NM_178156.2 NP_835369.1 alpha-(1,6)-fucosyltransferase isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables glycoprotein 6-alpha-L-fucosyltransferase activity IDA
IDA: Inferred from direct assay
17172260 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Références Source
involved in GDP-L-fucose metabolic process IDA
IDA: Inferred from direct assay
17172260 GOA
involved in protein N-linked glycosylation via asparagine IDA
IDA: Inferred from direct assay
17172260 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUT8 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (509 - 558)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 575 a.a.
Protein Preferred Names Protein Names

alpha-(1,6)-fucosyltransferase

  • GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase

FUT8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
FUT8 Q9BYC5 ZBTB10 Homo sapiens Q96DT7-3
Y2H Prey Pooling
32296183
Intra
FUT8 Q9BYC5 ZBTB10 Homo sapiens Q96DT7-3
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FUT8 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P75181 FUT8 Protein, Human (sf9, His) Q9BYC5-1 (R68-K575) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Congenital Disorder Of Glycosylation With Defective Fucosylation 1

  • CDGF1

  • Cdgf
Lipodystrophy, Congenital Generalized, Type 2

  • Congenital Generalized Lipodystrophy Type 2

  • CGL2

  • Berardinelli-Seip Congenital Lipodystrophy Type 2

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome Bscl2-Related

  • Total Lipodystrophy And Acromegaloid Gigantism

  • Berardinelli-Seip Congenital Lipodystrophy, Type 2

  • Seip Syndrome

  • Berardinelli Syndrome

  • Lipodystrophy, Total, And Acromegaloid Gigantism

  • Lipoatrophic Diabetes, Congenital

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 2

  • Brunzell Syndrome, Bscl2-Related

  • Congenital Lipoatrophic Diabetes

  • Congenital Generalized Lipodystrophy 2

  • Lipoatrophic Diabetes

  • Lipodystrophy Berardinelli Type

  • Familial Generalized Lipodystrophy

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Congenital Disorder Of Glycosylation, Type In

  • Congenital Disorder Of Glycosylation

  • CDG1N

  • Congenital Disorders Of Glycosylation

  • Cdg In

  • Cdgin

  • Congenital Disorder Of Glycosylation 1n

  • Carbohydrate-Deficient Glycoprotein Syndrome

  • Cdg

  • Rft1-Cdg

  • Cdg-In

  • Congenital Disorder Of Glycosylation Type In

  • Carbohydrate Deficient Glycoprotein Syndrome

  • Cdg Syndrome

  • Congenital Disorder Of Glycosylation In

  • Carbohydrate-Deficient Glycoprotein Syndromes

  • Cdg Syndrome Type In

  • Carbohydrate Deficient Glycoprotein Syndrome Type In

  • Congenital Disorder Of Glycosylation Type 1n

  • Man5glcnac2-Pp-Dol Flippase Deficiency

  • Glycosylation, Congenital Disorder Of

  • Glycosylation, Congenital Disorder Of, Type In
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-155747 FDW028 Inhibitor 99.51% Unkown
HY-E70157 Fucosyltransferase 8 / Unkown
HY-RS05159 FUT8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170541 FUT8-IN-1 Inhibitor / Unkown
HY-181989 CAIF Inhibitor / Unkown
HY-RS17190 Fut8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23641 Fut8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (21)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P99113A Inebilizumab (FUT8-KO) 99.84% Unkown
HY-P99010A Bemarituzumab (FUT8-KO) Inhibitor 99.74% Unkown
HY-P9980A Belantamab (FUT8-KO) 98.10% Unkown
HY-P9977A Amivantamab (FUT8-KO) Inhibitor 98% Unkown
HY-P99653A Ianalumab (FUT8-KO) Inhibitor 99.85% Unkown
HY-P99406A Petosemtamab (FUT8-KO) Degrader 99% Unkown
HY-P991942A Lanerkitug (FUT8-KO) Inhibitor 98.85% Unkown
HY-P991481A S-531011 (FUT8-KO) Inhibitor 99.10% Unkown
HY-P99226A Daxdilimab (FUT8-KO) Inhibitor 97% Unkown
HY-P990026A Ulviprubart (FUT8-KO) Inhibitor / Unkown
HY-P99014A Cusatuzumab (FUT8-KO) Inhibitor / Unkown
HY-P990755A Pamvatamig (FUT8-KO) Inhibitor / Unkown
HY-P991092A IBI-334 (FUT8-KO) Inhibitor / Unkown
HY-P991135A Enzelkitug (FUT8-KO) Inhibitor / Unkown
HY-P991514A MIL62 (FUT8-KO) Inhibitor / Unkown
HY-P991892A IT1208 (FUT8-KO) Inhibitor / Unkown
HY-P991944A ZL-1218 (FUT8-KO) Inhibitor / Unkown
HY-P992005A DS-1055a (FUT8-KO) Inhibitor / Unkown
HY-P99295A Imgatuzumab (FUT8-KO) Inhibitor / Unkown
HY-P99434A Amlitelimab (FUT8-KO) Inhibitor / Unkown
HY-P9991A Osemitamab (FUT8-KO) / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FUT8 VGNC VGNC:41015
Bos taurus FUT8 VGNC VGNC:29152
Macaca mulatta FUT8 VGNC VGNC:72829
Rattus norvegicus FUT8 RGD RGD:1303096
Mus musculus FUT8 MGD MGI:1858901
Felis catus FUT8 VGNC VGNC:62394
Others FUT8 NCBI