2. Neuronal Signaling
  3. Glucosylceramide Synthase (GCS)
  4. CAIF

CAIF is an irreversible, selective allosteric covalent inhibitor of ucosyltransferase 8 (FUT8) with an IC50 of 5.7 μM. CAIF inhibits core fucosylation modification in cancer cells, and suppresses the invasion and migration of cancer cells. CAIF is applicable for cancer research.

For research use only. We do not sell to patients.

CAIF

CAIF Chemical Structure

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CAIF Related Antibodies

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Description

CAIF is an irreversible, selective allosteric covalent inhibitor of ucosyltransferase 8 (FUT8) with an IC50 of 5.7 μM. CAIF inhibits core fucosylation modification in cancer cells, and suppresses the invasion and migration of cancer cells. CAIF is applicable for cancer research[1].

In Vitro

CAIF (0-500 μM; 72 h) exhibits extremely low cytotoxicity in HeLa, A375, GAK and HEK293T cells, with no toxicity detected at the concentration of 500 μM in HeLa and GAK cells[1].
CAIF (0-300 μM; 72 h) significantly inhibits core fucosylation in HeLa, A375 and GAK cells, with an EC50 of 38.4 μM in GAK cells[1].
CAIF (1-100 μM; 72 h) inhibits the invasion of HeLa cells in vitro, and its efficacy is superior to that of 2FF at the tested concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAIF Related Antibodies

Cell Invasion Assay[1]

Cell Line: HeLa
Concentration: 1, 10, 50, 100 μM
Incubation Time: 48 h (pretreatment); 24 h (invasion assay incubation at 37 °C)
Result: Outperformed 2FF in suppressing HeLa cell migration and invasion in the in vitro invasion assay.
Molecular Weight

556.58

Formula

C27H46BrN3O4
SMILES

C[N+]1=C(C)N(C=C1)CCCCCCCCCCCCCCCCCC(ON2C(CCC2=O)=O)=O.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CAIF Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAIFGlucosylceramide Synthase (GCS)colorectal cancerhead and neck squamous cell carcinomametastatic melanomacervical adenocarcinomaFUT8core fucosylationnon-small cell lung cancerlysine K216triple-negative breast cancerFucosyltransferase 8Inhibitorinhibitorinhibit

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