IT1208 (FUT8-KO)
IT1208 (FUT8-KO) is a humanized anti-CD4 monoclonal IgG1 antibody that has knocked out the fucosyltransferase 8 gene (FUT8). It exhibits enhanced antibody-mediated cytotoxicity (ADCC) effect. IT1208 (FUT8-KO) can effectively eliminate CD4+ T cells in vivo and shows controllable safety. IT1208 (FUT8-KO) can be used in related research on colon cancer.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Human B cell lymphoma Raji cells (1 × 106, i.p.) induced-mice prior to Healthy human peripheral blood mononuclear cells (PBMCs) (20 × 106, i.p.)[2]
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Dosage:200 μg
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Administration:i.p., twice a week for 4 weeks
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Result:Effectively prevented the development of xenogeneic GVHD in mice in experiments using cells from 3 donors.
Exerted only a partial preventive effect on xenogeneic GVHD in mice in the experiment using cells from 1 single donor.
Significantly prevented GVHD-associated damage to target tissues including the skin, salivary glands, liver and lung in mice.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Shitara K, et al., Matsushima K, Doi T. First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors. J Immunother Cancer. 2019 Jul 24;7(1):195. [Content Brief]
[2]. Liu M, Yang J, Xu B, Zhang X. Tumor metastasis: Mechanistic insights and therapeutic interventions. MedComm (2020). 2021 Dec 2;2(4):587-617. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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